Organic Field-Effect Transistors as Flexible, Tissue-Equivalent Radiation Dosimeters in Medical Applications.

X‐ray detection dosimetry flexible electronics organic field effect transistors radiation detection

Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 24 04 2020
revised: 04 06 2020
entrez: 1 10 2020
pubmed: 2 10 2020
medline: 2 10 2020
Statut: epublish

Résumé

Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field-effect transistor (RAD-OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors faced by current technologies in approximating the dose profile in a patient's body, is sensitive for doses relevant to radiation treatment procedures, and robust when incorporated into conformal large-area electronics. A model is proposed to describe the operation of RAD-OFETs, based on the interplay between charge photogeneration and trapping.

Identifiants

pubmed: 32999849
doi: 10.1002/advs.202001522
pii: ADVS1923
pmc: PMC7509662
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2001522

Informations de copyright

© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Andrew M Zeidell (AM)

Department of Physics and Center for Functional Materials Wake Forest University Winston-Salem NC 27109 USA.

Tong Ren (T)

Department of Radiation Oncology Wake Forest School of Medicine Wake Forest University Winston Salem NC 27157 USA.

David S Filston (DS)

Department of Physics and Center for Functional Materials Wake Forest University Winston-Salem NC 27109 USA.

Hamna F Iqbal (HF)

Department of Physics and Center for Functional Materials Wake Forest University Winston-Salem NC 27109 USA.

Emma Holland (E)

University of Kentucky Center for Applied Energy Research Lexington KY 40511 USA.

J Daniel Bourland (JD)

Department of Radiation Oncology Wake Forest School of Medicine Wake Forest University Winston Salem NC 27157 USA.

John E Anthony (JE)

University of Kentucky Center for Applied Energy Research Lexington KY 40511 USA.

Oana D Jurchescu (OD)

Department of Physics and Center for Functional Materials Wake Forest University Winston-Salem NC 27109 USA.

Classifications MeSH