Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis: A Prospective Observational Exploratory Study.
Blood glucose variability
Continuous glucose monitoring
DPP-4 inhibitors
Hemodialysis
Hypoglycemia
Journal
Diabetes therapy : research, treatment and education of diabetes and related disorders
ISSN: 1869-6953
Titre abrégé: Diabetes Ther
Pays: United States
ID NLM: 101539025
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
20
07
2020
accepted:
11
09
2020
pubmed:
2
10
2020
medline:
2
10
2020
entrez:
1
10
2020
Statut:
ppublish
Résumé
The precise blood glucose (BG) profile of hemodialysis patients is unclear, as is the effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors in hemodialysis patients with type 2 diabetes. Here, we used continuous glucose monitoring (CGM) to evaluate BG variability in these patients and to assess the efficacy of DPP-4 inhibitors, particularly during hemodialysis sessions and at nighttime (UMIN000012638). We examined BG profiles using CGM in 31 maintenance hemodialysis patients with type 2 diabetes. Differences between patients with and without DPP-4 inhibitors (n = 15 and 16, respectively) were analyzed using a linear mixed-effects model to assess changes in glucose levels in 5-min intervals. The model revealed that DPP-4 inhibitor use was significantly associated with suppression of a rapid drop in glucose levels, both with and without adjustment for BG levels at the start of hemodialysis. Moreover, the model revealed that the two groups differed significantly in the pattern of changes in BG levels from 0:00 to 6:55 am. DPP-4 inhibitors suppressed the tendency for subsequent nocturnal hypoglycemia. This prospective observational exploratory study showed that DPP-4 inhibitors could suppress BG variability during hemodialysis sessions as well as subsequent nocturnal changes in patients with type 2 diabetes. ClinicalTrials.gov identifier, UMIN000012638.
Identifiants
pubmed: 33000383
doi: 10.1007/s13300-020-00928-5
pii: 10.1007/s13300-020-00928-5
pmc: PMC7644617
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2845-2861Références
Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E129-35
pubmed: 12824085
Cardiovasc Diabetol. 2012 Aug 06;11:92
pubmed: 22867630
Diabetes. 2002 Mar;51(3):724-33
pubmed: 11872673
Diabetes. 2011 Dec;60(12):3103-9
pubmed: 21984584
World J Diabetes. 2015 Jun 25;6(6):840-9
pubmed: 26131325
Adv Ther. 2016 Jul;33(7):1215-30
pubmed: 27255763
Clin Nephrol. 2000 Jul;54(1):30-4
pubmed: 10939754
Ther Apher Dial. 2009 Apr;13(2):95-102
pubmed: 19379147
Diabetes. 2012 Mar;61(3):708-15
pubmed: 22315308
Diabetes. 1999 Feb;48(2):261-6
pubmed: 10334299
N Engl J Med. 2010 Oct 7;363(15):1410-8
pubmed: 20925543
Diabetes Ther. 2014 Jun;5(1):1-41
pubmed: 24664619
Am J Kidney Dis. 2005 Apr;45(4 Suppl 3):S1-153
pubmed: 15806502
Diabetes. 2000 Jul;49(7):1186-93
pubmed: 10909977
Diabetes Technol Ther. 2013 Mar;15(3):237-40
pubmed: 23402316
J Atheroscler Thromb. 2017 Feb 1;24(2):157-168
pubmed: 27397060
Int Urol Nephrol. 2016 Feb;48(2):265-70
pubmed: 26725077
J Diabetes Res. 2016;2016:9849328
pubmed: 26798658
Cardiovasc Diabetol. 2020 Jan 7;19(1):1
pubmed: 31910850
Blood Purif. 2014;38(1):68-73
pubmed: 25300368
Diabetes Technol Ther. 2013 May;15(5):378-85
pubmed: 23634671
Clin J Am Soc Nephrol. 2009 Jun;4(6):1121-7
pubmed: 19423569
Diabetes Technol Ther. 2010 Oct;12(10):801-7
pubmed: 20809681
Diabetes Care. 2003 May;26(5):1485-9
pubmed: 12716809
Diabetes Obes Metab. 2018 Sep;20(9):2274-2281
pubmed: 29770541
J Diabetes Complications. 2015 Apr;29(3):395-9
pubmed: 25681043
Endocrinol Metab Clin North Am. 1989 Mar;18(1):103-21
pubmed: 2645122
Diabetes. 1999 Feb;48(2):292-8
pubmed: 10334304
Diabetes. 1970 Sep;19(9):644-55
pubmed: 5469118
Expert Opin Pharmacother. 2017 Aug;18(12):1179-1186
pubmed: 28714741
Diabetes Ther. 2017 Oct;8(5):1111-1122
pubmed: 28921310
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2275-80
pubmed: 16888238
Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E419-27
pubmed: 11788375
Diabetes Care. 2010 Jul;33(7):1591-7
pubmed: 20587725
Nephrology (Carlton). 2010 Sep;15(6):632-8
pubmed: 20883284
Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1049-56
pubmed: 15304374
Diabetes Care. 2016 Apr;39(4):502-10
pubmed: 27208366
Vasc Health Risk Manag. 2014;10:15-24
pubmed: 24391442
Clin Exp Nephrol. 2015 Jun;19(3):527-33
pubmed: 25139482
Horm Metab Res. 2014 Oct;46(11):810-3
pubmed: 24627097
N Engl J Med. 2008 Jun 12;358(24):2545-59
pubmed: 18539917
Contrib Nephrol. 2015;185:98-115
pubmed: 26023019
Diabetes Res Clin Pract. 2015 Mar;107(3):348-54
pubmed: 25638452
Kidney Int. 1994 Sep;46(3):814-22
pubmed: 7996803
Nephrol Dial Transplant. 1998 Dec;13(12):2996-9
pubmed: 9870450
Clin Nephrol. 1999 Apr;51(4):242-7
pubmed: 10230557
JAMA. 2006 Apr 12;295(14):1681-7
pubmed: 16609090
Diabetes Res Clin Pract. 2010 Oct;90(1):22-5
pubmed: 20705354
Lancet. 2006 Nov 11;368(9548):1696-705
pubmed: 17098089
Medicine (Baltimore). 2016 Oct;95(43):e5229
pubmed: 27787387
Diabetes Care. 2009 Jul;32(7):1137-42
pubmed: 19196889
Diabetes Technol Ther. 2014 Dec;16(12):840-5
pubmed: 25144424
J Bras Nefrol. 2012 Oct-Dec;34(4):323-7
pubmed: 23318819
N Engl J Med. 2004 May 27;350(22):2272-9
pubmed: 15163777
Diabetes Care. 2010 Apr;33(4):730-2
pubmed: 20067974
J Am Soc Nephrol. 2015 Nov;26(11):2621-33
pubmed: 26209712
Kidney Int. 2000 Mar;57(3):1176-81
pubmed: 10720970
Diabetologia. 2005 Sep;48(9):1700-13
pubmed: 16132964
Nephrol Dial Transplant. 2012 Apr;27(4):1559-68
pubmed: 21940484
Diabetologia. 2007 Jun;50(6):1170-7
pubmed: 17393134
J Diabetes Complications. 2017 Jan;31(1):280-287
pubmed: 27818105
Hemodial Int. 2014 Apr;18(2):423-32
pubmed: 24274900
Diabetes Obes Metab. 2020 Jun;22(6):978-987
pubmed: 32048396
Clin Nephrol. 2004 Nov;62(5):362-8
pubmed: 15571181
Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E428-34
pubmed: 11788376
Cardiovasc Diabetol. 2011 Feb 25;10:19
pubmed: 21349201
Diabetes Obes Metab. 2020 Mar;22(3):458-462
pubmed: 31486230
Diabetes Obes Metab. 2020 Feb;22(2):173-181
pubmed: 31502749
Diabetologia. 2007 Jun;50(6):1148-55
pubmed: 17387446
J Clin Endocrinol Metab. 2009 Apr;94(4):1236-43
pubmed: 19174497
Nephrol Dial Transplant. 2007 Apr;22(4):1184-9
pubmed: 17272314
Diabetes Care. 2001 May;24(5):909-13
pubmed: 11347753
Diabetes Ther. 2020 Mar;11(3):701-710
pubmed: 32020552
Nephrol Dial Transplant. 2009 Sep;24(9):2866-71
pubmed: 19389864
Diabetes Technol Ther. 2011 Jul;13(7):699-703
pubmed: 21504334
Diabetes Technol Ther. 2010 Oct;12(10):749-53
pubmed: 20809678
J Diabetes Investig. 2019 May;10(3):714-722
pubmed: 30171747
Diabetes Care. 1987 Mar-Apr;10(2):225-37
pubmed: 3582083