Catechols: a new class of carbonic anhydrase inhibitors.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
04 Nov 2020
04 Nov 2020
Historique:
pubmed:
2
10
2020
medline:
18
5
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water".
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Catechols
0
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM