First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)".

Adolescent Adult Age Factors Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / adverse effects Body Mass Index COVID-19 / diagnosis Cardiovascular Diseases / diagnosis Cohort Studies Comorbidity Diabetes Mellitus / diagnosis Europe / epidemiology Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects Kidney Diseases / diagnosis Logistic Models Lung Diseases / diagnosis Male Middle Aged Pandemics SARS-CoV-2 / pathogenicity Severity of Illness Index Sex Factors
COVID-19 Cohort study LEOSS SARS-CoV-2

Journal

Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 25 05 2020
accepted: 01 08 2020
pubmed: 2 10 2020
medline: 10 2 2021
entrez: 1 10 2020
Statut: ppublish

Résumé

Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42, p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81, p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

Identifiants

DOI: 10.1007/s15010-020-01499-0 PMID: 33001409 PMC: PMC7527665
pubmed: 33001409
doi: 10.1007/s15010-020-01499-0
pii: 10.1007/s15010-020-01499-0
pmc: PMC7527665
doi:

Substances chimiques

Angiotensin-Converting Enzyme Inhibitors 0
Hydroxymethylglutaryl-CoA Reductase Inhibitors 0

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-73

Références

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Auteurs

Carolin E M Jakob (CEM)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
German Center for Infection Research (DZIF), Brunswick, Germany.

Stefan Borgmann (S)

Department of Infectious Diseases and Infection Control, Ingolstadt Hospital, Ingolstadt, Germany.

Fazilet Duygu (F)

Department of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, Frankfurt, Germany.

Uta Behrends (U)

German Center for Infection Research (DZIF), Brunswick, Germany.
Technical University Munich, Children's Hospital, Munich, Germany.
Research Unit Gene Vectors, Helmholtz Zentrum Muenchen, Munich, Germany.

Martin Hower (M)

Clinic for Pneumology, Infectiology, Internal Medicine and Intensive Care, Hospital Dortmund gGmbH, Dortmund, Germany.

Uta Merle (U)

Department of Gastroenterology and Infectiology, Heidelberg University Hospital, Heidelberg, Germany.

Anette Friedrichs (A)

Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.

Lukas Tometten (L)

Department of Gastroenterology and Infectiology, Klinikum Ernst-von-Bergmann, Potsdam, Germany.

Frank Hanses (F)

Emergency Department, University Hospital Regensburg, Regensburg, Germany.

Norma Jung (N)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Siegbert Rieg (S)

Department of Medicine II, University of Freiburg, Freiburg, Germany.

Kai Wille (K)

University Clinic for Haematology, Oncology, Haemostaseology and Palliative Care, University of Bochum, Minden, Germany.

Beate Grüner (B)

Division of Infectious Diseases, Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.

Hartwig Klinker (H)

Division of Infectious Diseases, Department of Medicine II, University of Würzburg Medical Center, Würzburg, Germany.

Nicole Gersbacher-Runge (N)

Center of Infectiology Berlin/Prenzlauer Berg, Berlin, Germany.

Kerstin Hellwig (K)

Department of Neurology, Katholisches Klinikum Bochum, Ruhr University Bochum, Bochum, Germany.

Lukas Eberwein (L)

4th Department of Internal Medicine, Klinikum Leverkusen gGmbH, Leverkusen, Germany.

Sebastian Dolff (S)

Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Dominic Rauschning (D)

Bundeswehr Central Hospital, Koblenz, Germany.

Michael von Bergwelt-Baildon (M)

Department of Internal Medicine III, Ludwig Maximilians University, Munich, Germany.
German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
Bavarian Center for Cancer Research (BZKF), Munich, Germany.

Julia Lanznaster (J)

2nd Medical Clinic, Hospital Passau, Passau, Germany.

Richard Strauß (R)

Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany.

Janina Trauth (J)

Medical Clinic II, University Hospital Gießen, Giessen, Germany.

Katja de With (K)

Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.

Maria Ruethrich (M)

Department of Internal Medicine II, University Hospital Jena, Jena, Germany.

Catherina Lueck (C)

Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Jacob Nattermann (J)

German Center for Infection Research (DZIF), Brunswick, Germany.
Department of Internal Medicine I, UKB University Hospital Bonn, Bonn, Germany.

Lene Tscharntke (L)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Lisa Pilgram (L)

Department of Internal Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany.

Sandra Fuhrmann (S)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Annika Classen (A)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
German Center for Infection Research (DZIF), Brunswick, Germany.

Melanie Stecher (M)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
German Center for Infection Research (DZIF), Brunswick, Germany.

Maximilian Schons (M)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Christoph Spinner (C)

German Center for Infection Research (DZIF), Brunswick, Germany.
Department of Internal Medicine II, School of Medicine, Technical University of Munich, University Hospital Rechts Der Isar, Munich, Germany.

Jörg Janne Vehreschild (JJ)

Department I for Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany. joerg.vehreschild@uk-koeln.de.
German Center for Infection Research (DZIF), Brunswick, Germany. joerg.vehreschild@uk-koeln.de.
Department of Internal Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany. joerg.vehreschild@uk-koeln.de.

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