Huangjinya Black Tea Alleviates Obesity and Insulin Resistance via Modulating Fecal Metabolome in High-Fat Diet-Fed Mice.
Adipose Tissue, White
/ growth & development
Animals
Camellia sinensis
/ genetics
Diet, High-Fat
/ adverse effects
Feces
/ chemistry
Gastrointestinal Microbiome
/ physiology
Hyperglycemia
/ diet therapy
Hyperlipidemias
/ diet therapy
Insulin Resistance
Male
Mice, Inbred BALB C
Non-alcoholic Fatty Liver Disease
/ diet therapy
Obesity
/ diet therapy
Tea
/ chemistry
Huangjinya
black tea
fecal metabolome
lipolysis
liver steatosis
obesity
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
12
04
2020
revised:
04
09
2020
pubmed:
2
10
2020
medline:
25
8
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
Huangjinya is a light-sensitive tea mutant containing low levels of tea polyphenols. Currently, most studies focused on characteristics formation, free amino acid metabolism and phytochemical purification. The biological activity of Huangjinya black tea (HJBT) on metabolic syndrome regarding fecal metabolome modulation is unavailable and is studied herein. High-fat diet (HFD)-fed mice are treated with HJBT for 9 weeks, various metabolic biomarkers and fecal metabolites are determined. HJBT reduces adipogenic and lipogenic gene expression, enhances lipolytic gene expression, decreases adipocyte expansion, and prevents the development of obesity. HJBT reduces lipogenic gene expression, increases fatty acid oxidation-related genes expression, which alleviates liver steatosis. HJBT enhances glucose/insulin tolerance, increases insulin/Akt signaling, attenuates hyperlipidemia and hyperglycemia, prevents the onset of insulin resistance. HJBT modulates bile acid metabolism, promotes secondary/primary bile acid ratio; increases short-chain fatty acids production, promotes saturated and polyunsaturated fatty acids content; reduces carnitines and phosphocholines, but increases myo-inositol content; decreases branched-chain and aromatic amino acids content; increases the metabolite content related to pentose phosphate pathway. This study reported the association between fecal metabolome modulation and metabolism improvement due to HJBT administration, proposes HJBT as a dietary intervention for preventing obesity and metabolic disorders.
Identifiants
pubmed: 33002297
doi: 10.1002/mnfr.202000353
doi:
Substances chimiques
Tea
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000353Informations de copyright
© 2020 Wiley-VCH GmbH.
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