Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.

Adult Brain / diagnostic imaging Hippocampus / diagnostic imaging Humans Memory Microglia Neuroimaging Positron-Emission Tomography
Hippocampus Microglia Neuroinflammation PBR28 Verbal memory

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
01 2021
Historique:
received: 10 06 2020
revised: 01 09 2020
accepted: 23 09 2020
pubmed: 2 10 2020
medline: 28 5 2021
entrez: 1 10 2020
Statut: ppublish

Résumé

Psychiatric and neurologic disorders are often characterized by both neuroinflammation and cognitive dysfunction. To date, however, the relationship between neuroinflammation and cognitive dysfunction remains understudied in humans. Preclinical research indicates that experimental induction of neuroinflammation reliably impairs memory processes. In this paradigm development study, we translated those robust preclinical findings to humans using positron emission tomography (PET) imaging with [

Identifiants

DOI: 10.1016/j.bbi.2020.09.027 PMID: 33002632 PMC: PMC7749814
pubmed: 33002632
pii: S0889-1591(20)31316-7
doi: 10.1016/j.bbi.2020.09.027
pmc: PMC7749814
mid: NIHMS1637254
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

784-787

Subventions

Organisme : NIAAA NIH HHS
ID : K01 AA024788
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA048125
Pays : United States
Organisme : NIDA NIH HHS
ID : K02 DA031750
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA022975
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110674
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Références

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Auteurs

Eric A Woodcock (EA)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States.

Ansel T Hillmer (AT)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.

Christine M Sandiego (CM)

Invicro, New Haven, CT, United States.

Paul Maruff (P)

Cogstate Ltd., and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.

Richard E Carson (RE)

Yale PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.

Kelly P Cosgrove (KP)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Yale PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States. Electronic address: kelly.cosgrove@yale.edu.

Robert H Pietrzak (RH)

Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, United States.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Acute neuroimmune stimulation impairs verbal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Acute neuroimmune stimulation impairs verbal...