Pressure Pain Threshold in Patients With Chronic Pain: A Systematic Review and Meta-Analysis.
Journal
American journal of physical medicine & rehabilitation
ISSN: 1537-7385
Titre abrégé: Am J Phys Med Rehabil
Pays: United States
ID NLM: 8803677
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
pubmed:
2
10
2020
medline:
28
7
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
In chronic pain conditions, the pressure pain threshold has been used to investigate the presence of central sensitization. A systematic review and meta-analysis were conducted to compare the threshold in chronic pain patients and healthy individuals. Ovid MEDLINE and Embase up to July 2019 were used to conduct the search. Search strategy included terms and sets of terms that describe the concepts "sensory testing" and "pain measurement." The included studies consisted of 24 were case-control studies and 12 cross-sectional studies. The pooled total sample size was 1280 cases of patients with different diagnoses of chronic pain and 1463 healthy controls. Among the included studies, 32 reported a significant decrease of the pressure pain threshold among patients compared with the controls and four reported no statistically significant difference. The pooled pressure pain threshold mean difference was -1.17 (95% confidence interval = -1.45 to -0.90). There was, however, evidence of significant heterogeneity across the studies (I2 = 87.42%, P < 0.001). Patients who experience chronic pain have a significantly lower pressure pain threshold compared with healthy controls. Future research is needed to elucidate factors attributed to the change in pressure pain threshold among patients with chronic pain, as well as the time that the central sensitization occurs.
Identifiants
pubmed: 33002911
pii: 00002060-202107000-00008
doi: 10.1097/PHM.0000000000001603
doi:
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
656-674Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.
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