The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study.
altitude
cutaneous melanoma
miRNA
molecular profiling
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Sep 2020
29 Sep 2020
Historique:
received:
14
07
2020
revised:
04
09
2020
accepted:
22
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
Cutaneous melanoma (CM) incidence is rising worldwide and is the primary cause of death from skin disease in the Western world. Personal risk factors linked to environmental ultraviolet radiation (UVR) are well-known etiological factors contributing to its development. Nevertheless, UVR can contribute to the development of CM in different patterns and to varying degrees. The present study aimed at investigating whether altitude of residence can contribute to the development of specific types of CM and/or influence its progression. To this aim, 306 formalin-fixed and paraffin-embedded (FFPE) tissues from primary CM diagnosed in different geographical areas were submitted to B-RAF proto-oncogene serine/threonine kinase (BRAF) and N-RAS proto-oncogene GTPase (NRAS) mutational status detection and mRNA and miRNA profiling by qPCR. Genes were chosen for their functions in specific processes, such as immune response (
Identifiants
pubmed: 33003444
pii: cancers12102796
doi: 10.3390/cancers12102796
pmc: PMC7599639
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Interreg
ID : ITAT1018
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