Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.
aging
biomarkers
gut microbiome
metabolome
sulforaphane
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
29 Sep 2020
29 Sep 2020
Historique:
received:
30
07
2020
revised:
12
09
2020
accepted:
27
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6-8 weeks) and old (21-22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera,
Identifiants
pubmed: 33003447
pii: microorganisms8101500
doi: 10.3390/microorganisms8101500
pmc: PMC7599699
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : AG032643
Pays : United States
Organisme : American Heart Association
ID : 14GRNT18890084
Organisme : NIH HHS
ID : GM109005
Pays : United States
Organisme : NIH HHS
ID : CA051008
Pays : United States
Organisme : National Science Foundation
ID : OIA 1946391
Références
Aging (Albany NY). 2019 Jan 15;11(2):289-290
pubmed: 30648974
Cell. 2014 Nov 6;159(4):789-99
pubmed: 25417156
BMC Microbiol. 2014 Dec 14;14:311
pubmed: 25495462
Nat Commun. 2019 Oct 3;10(1):4505
pubmed: 31582752
Curr Opin Microbiol. 2017 Feb;35:8-15
pubmed: 27883933
Oxid Med Cell Longev. 2019 Jul 11;2019:2860642
pubmed: 31379987
Int J Obes (Lond). 2019 Jan;43(1):149-157
pubmed: 29777234
Elife. 2016 Nov 22;5:
pubmed: 27874830
mSystems. 2016 Jan-Feb;1(1):
pubmed: 27239563
Austin J Cerebrovasc Dis Stroke. 2017;4(1):
pubmed: 29619410
J Proteome Res. 2010 May 7;9(5):2786-93
pubmed: 20329776
Front Microbiol. 2017 Sep 22;8:1765
pubmed: 29018410
Obesity (Silver Spring). 2012 Apr;20(4):738-47
pubmed: 21593810
Proc Nutr Soc. 2017 Aug;76(3):265-275
pubmed: 27819203
Microbiome. 2017 Aug 18;5(1):105
pubmed: 28821301
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
World J Gastroenterol. 2015 Aug 7;21(29):8787-803
pubmed: 26269668
BMC Microbiol. 2009 Jun 09;9:123
pubmed: 19508720
J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):571-578
pubmed: 29045670
EMBO Rep. 2015 Feb;16(2):164-77
pubmed: 25525071
Nucleic Acids Res. 2002 Jul 15;30(14):3059-66
pubmed: 12136088
Environ Microbiol. 2017 Mar;19(3):835-841
pubmed: 28028921
World J Clin Cases. 2015 Feb 16;3(2):156-62
pubmed: 25685762
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:140-8
pubmed: 26596842
Cell. 2018 Sep 6;174(6):1388-1405.e21
pubmed: 30193112
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
J Am Geriatr Soc. 2015 Apr;63(4):776-81
pubmed: 25851728
mBio. 2014 Apr 22;5(2):e00889
pubmed: 24757212
Cell Immunol. 2014 May-Jun;289(1-2):112-8
pubmed: 24759078
PLoS One. 2012;7(8):e42529
pubmed: 22880019
Physiol Genomics. 2018 Apr 1;50(4):244-254
pubmed: 29373083
Mol Biosyst. 2013 Feb 2;9(2):307-17
pubmed: 23247761
Aging Cell. 2020 Oct 17;:e13261
pubmed: 33067900
Horm Metab Res. 2011 Apr;43(4):241-3
pubmed: 21264793
Nutr Healthy Aging. 2018 Jun 15;4(4):267-285
pubmed: 29951588
ISME J. 2013 Apr;7(4):707-17
pubmed: 23190729
Br J Pharmacol. 2002 Nov;137(6):855-60
pubmed: 12411417
Int J Syst Evol Microbiol. 2003 Jan;53(Pt 1):211-215
pubmed: 12656175
Nucleic Acids Res. 2018 Jan 4;46(D1):D633-D639
pubmed: 29059334
Cell Metab. 2015 Dec 1;22(6):971-82
pubmed: 26552345
Nat Biotechnol. 2020 Jun;38(6):685-688
pubmed: 32483366
ISME J. 2012 Mar;6(3):610-8
pubmed: 22134646
Mol Cell. 2016 Jan 21;61(2):199-209
pubmed: 26725009
Front Cell Infect Microbiol. 2019 Feb 04;9:4
pubmed: 30778376
Cell. 2018 Sep 6;174(6):1406-1423.e16
pubmed: 30193113
Biomed Res Int. 2017;2017:1829685
pubmed: 28299315
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62
pubmed: 26476454
Obesity (Silver Spring). 2013 Dec;21(12):E607-15
pubmed: 23526699
Lancet Oncol. 2018 Jun;19(6):e295-e304
pubmed: 29893261
Geroscience. 2019 Oct;41(5):655-670
pubmed: 30941620
ISME J. 2014 Oct;8(10):2116-30
pubmed: 24694712
Signal Transduct Target Ther. 2019 Oct 12;4:41
pubmed: 31637019
Benef Microbes. 2014 Sep;5(3):235-46
pubmed: 24889891
PeerJ. 2016 Oct 18;4:e2584
pubmed: 27781170
mSystems. 2019 Jun 4;4(3):
pubmed: 31164406
Nature. 2012 Aug 9;488(7410):178-84
pubmed: 22797518
Microb Inform Exp. 2011 Jun 14;1(1):4
pubmed: 22587810
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Nat Med. 2019 May;25(5):716-729
pubmed: 31061539
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Pediatr Obes. 2019 Apr;14(4):e12480
pubmed: 30417607
Appl Environ Microbiol. 2005 Dec;71(12):8228-35
pubmed: 16332807
Nat Methods. 2013 Jan;10(1):57-9
pubmed: 23202435
PLoS One. 2010 Mar 10;5(3):e9490
pubmed: 20224823
EXCLI J. 2016 Oct 13;15:571-577
pubmed: 28096787
Molecules. 2017 Feb 13;22(2):
pubmed: 28208818
Microbiome. 2018 May 17;6(1):90
pubmed: 29773078
PLoS One. 2016 Mar 25;11(3):e0152126
pubmed: 27015276
Nat Commun. 2019 Jul 17;10(1):3136
pubmed: 31316056
Nat Rev Gastroenterol Hepatol. 2016 Feb;13(2):69-70
pubmed: 26828918
Nature. 2013 Aug 29;500(7464):585-8
pubmed: 23985875
Magn Reson Med. 1991 Nov;22(1):128-32
pubmed: 1798387
ISME J. 2010 Feb;4(2):232-41
pubmed: 19865183
Appl Environ Microbiol. 2007 Mar;73(5):1576-85
pubmed: 17220268
Arch Biochem Biophys. 1997 May 1;341(1):98-103
pubmed: 9143358
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476
pubmed: 15388697
Mucosal Immunol. 2016 Jan;9(1):24-37
pubmed: 25921339
Nat Commun. 2013;4:2163
pubmed: 23860099
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288
mSystems. 2019 Jul 9;4(4):
pubmed: 31289141