Complete Loss of EPCAM Immunoexpression Identifies
EPCAM
colon polyps
colorectal cancer
immunohistochemistry
lynch syndrome
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Sep 2020
29 Sep 2020
Historique:
received:
25
07
2020
revised:
23
09
2020
accepted:
26
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
The use of epithelial cell adhesion molecule (EPCAM) immunohistochemistry (IHC) is not included in the colorectal cancer (CRC) screening algorithm to detect Lynch syndrome (LS) patients. The aim of the present study was to demonstrate that EPCAM IHC is a useful tool to guide the LS germ-line analysis when a loss of MSH2 expression was present. We retrospectively studied MSH2 and EPCAM IHC in a large series of 190 lesions composed of malignant neoplasms (102), precursor lesions of gastrointestinal (71) and extra-gastrointestinal origin (9), and benign neoplasms (8) from different organs of 71 patients suspicious of being LS due to
Identifiants
pubmed: 33003511
pii: cancers12102803
doi: 10.3390/cancers12102803
pmc: PMC7599495
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI17/01304; PI16/00766; PI19/01867
Organisme : Agencia de Gestió d'Ajuts Universitaris i de Recerca
ID : 2017SGR653; 2017 SGR 1035
Organisme : Research Project Award, Hospital Universitari General de Catalunya
ID : 2018
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