Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.
Adult
Antioxidants
/ administration & dosage
Biomarkers
/ metabolism
Blood Glucose
/ metabolism
DNA Damage
/ drug effects
Deoxyglucose
/ metabolism
Diabetes Mellitus
/ metabolism
Electrolysis
Female
Fructosamine
/ metabolism
Humans
Hydrogen
/ administration & dosage
Hydroxyl Radical
/ chemistry
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Water
/ administration & dosage
DNA-oxidative injuries
alternating current-electrolysis
antioxidant activity
diabetes
hydrogen-rich water
reactive oxygen species
Journal
Medical gas research
ISSN: 2045-9912
Titre abrégé: Med Gas Res
Pays: Australia
ID NLM: 101564536
Informations de publication
Date de publication:
Historique:
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
30
7
2021
Statut:
ppublish
Résumé
Hydrogen-rich water is conventionally prepared by direct current-electrolysis, but has been not or scarcely prepared by alternating current (AC)-electrolysis. The AC preparations from tap water for 20-30 minutes exhibit a dissolved hydrogen concentration of 1.55 mg/L, which was close to the theoretical maximum value of 1.6 mg/L. These preparations also displayed an oxidation-reduction potential of -270 mV (tap water: +576 mV) and pH of 7.7-7.8, being closer to physiological values of body fluids than general types of direct current-electrolytic hydrogen-rich water. We examined whether AC-electrolytic hydrogen-water is retained for hydrogen-abundance after boiling or for antioxidant abilities, and whether the oral administration of this water is clinically effective for diabetes and prevention against systemic DNA-oxidative injuries. 5,5-Dimethyl-1-pyrroline-N-oxide spin trapping and electron spin resonance revealed that the hydrogen-rich water generated by AC-electrolysis exhibited hydroxyl-radical-scavenging activities. Laser nanoparticle tracking method revealed that nanoparticle suspensions as abundant as 5.4 × 10
Identifiants
pubmed: 33004708
pii: MedGasRes_2020_10_3_114_296041
doi: 10.4103/2045-9912.296041
pmc: PMC8086617
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Blood Glucose
0
Reactive Oxygen Species
0
Water
059QF0KO0R
Hydroxyl Radical
3352-57-6
Fructosamine
4429-04-3
1,5-anhydroglucitol
54BB3B7XMZ
Hydrogen
7YNJ3PO35Z
Deoxyglucose
9G2MP84A8W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114-121Déclaration de conflit d'intérêts
None
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