ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.
Adult
Aged
Alanine Transaminase
/ blood
Alcohol Drinking
/ blood
Aldehyde Dehydrogenase, Mitochondrial
/ genetics
Aspartate Aminotransferases
/ blood
Cohort Studies
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Japan
/ epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
24
03
2020
accepted:
11
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
13
1
2021
Statut:
epublish
Résumé
Liver tests (LT), especially to measure AST, ALT and GGT levels, are widely used to evaluate the risk of alcohol-related liver disease (ALD). In this study, we investigated the potential genetic factors that modulate the association between LTs and alcohol consumption. We conducted a genome-wide interaction meta-analysis in 7856 Japanese subjects from Tohoku Medical Megabank Community-Based Cohort (TMM CommCohort) study recruited in 2013, and identified 2 loci (12q24 and 2p16) with genome-wide significance (P > 5 × 10
Identifiants
pubmed: 33004991
doi: 10.1038/s41598-020-73263-1
pii: 10.1038/s41598-020-73263-1
pmc: PMC7530747
doi:
Substances chimiques
ALDH2 protein, human
EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
Aspartate Aminotransferases
EC 2.6.1.1
Alanine Transaminase
EC 2.6.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16227Références
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