Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital.
Anti-cancer drug
Hair
Hospital
Inductively coupled plasma mass spectrometry
Platinum
Journal
Journal of occupational medicine and toxicology (London, England)
ISSN: 1745-6673
Titre abrégé: J Occup Med Toxicol
Pays: England
ID NLM: 101245790
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
11
2019
accepted:
03
09
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers. Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry. Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers ( Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers' hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues.
Sections du résumé
BACKGROUND
BACKGROUND
Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers.
METHODS
METHODS
Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry.
RESULTS
RESULTS
Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (
CONCLUSION
CONCLUSIONS
Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers' hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues.
Identifiants
pubmed: 33005211
doi: 10.1186/s12995-020-00280-1
pii: 280
pmc: PMC7523399
doi:
Types de publication
Journal Article
Langues
eng
Pagination
29Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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