Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation.
acute liver failure
dlbcl
lactic acidosis
secondary hepatic lymphoma
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
29 Aug 2020
29 Aug 2020
Historique:
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
Liver involvement by non-Hodgkin's lymphoma is common in late stage disease but rarely results in severe hepatic dysfunction. Here, we discuss a case of acute liver failure (ALF) with severe lactic acidosis in a 75-year-old female with diffuse large B-cell lymphoma (DLBCL). The patient was admitted with nausea, fevers, and mild acidosis. Although radiographic imaging did not demonstrate any liver abnormality, the patient soon developed signs of ALF along with severe lactic acidosis. Despite initiation of chemotherapy, the patient deteriorated quickly and was ultimately put on comfort measures. This case highlights an uncommon manifestation of DLBCL and suggests that an accelerated timeline for beginning chemotherapy may be warranted in patients with high clinical suspicion of secondary hepatic lymphoma.
Identifiants
pubmed: 33005528
doi: 10.7759/cureus.10110
pmc: PMC7523539
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e10110Informations de copyright
Copyright © 2020, Hafner et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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