Four-week inhalation toxicity study of 1-propanol in F344 rats.
1-Propanol
Inhalation toxicity
No-observed-adverse-effect level
Occupational exposure
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
19
07
2019
revised:
05
11
2019
accepted:
27
11
2019
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
1-Propanol is used as a solvent for waxes, vegetable oils, resins, cellulose esters, and ethers, and is not considered harmful to humans by food and non-occupational exposures. However, workers are potentially exposed to 1-propanol by inhalation when it is used in the workplace. Thus, inhalation toxicity data are needed to assess the hazard of 1-propanol for workers safety. Five male and five female F344 rats were exposed to 1-propanol vapor for 4-weeks (6 h/day, 5 days/week) at concentrations of 0, 100, 400, and 1600 ppm in a whole-body inhalation chamber system. The actual exposure concentrations were 100.11 ± 5.10, 403.19 ± 12.31, and 1598.08 ± 139.58 ppm for the low, middle, and high dose groups, respectively. No clinical signs, significant mean body weight changes, significant changes of hematology or blood biochemistry results, or histopathological abnormalities were seen related to exposure to the test substance. Under the conditions of this study, the no-observed-adverse-effect level of 1-propanol was over 1600 ppm.
Identifiants
pubmed: 33005587
doi: 10.1007/s43188-019-00033-1
pii: 33
pmc: PMC7494695
doi:
Types de publication
Journal Article
Langues
eng
Pagination
285-292Informations de copyright
© Korean Society of Toxicology 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no conflict of interest to disclose.
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