Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.
ALS
TBK1
ageing
inflammation
neurogenetics
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
03
2020
revised:
21
07
2020
accepted:
27
07
2020
entrez:
2
10
2020
pubmed:
3
10
2020
medline:
3
10
2020
Statut:
epublish
Résumé
Loss-of-function mutations in TANK-binding kinase 1 cause genetic amyotrophic lateral sclerosis and frontotemporal dementia. Consistent with incomplete penetrance in humans, haploinsufficiency of TANK-binding kinase 1 did not cause motor symptoms in mice up to 7 months of age in a previous study. Ageing is the strongest risk factor for neurodegenerative diseases. Hypothesizing that age-dependent processes together with haploinsufficiency of TANK-binding kinase 1 could create a double hit situation that may trigger neurodegeneration, we examined mice with hemizygous deletion of
Identifiants
pubmed: 33005894
doi: 10.1093/braincomms/fcaa133
pii: fcaa133
pmc: PMC7519725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcaa133Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Nat Commun. 2015 Jan 12;6:6047
pubmed: 25581158
J Immunother Cancer. 2017 Feb 21;5:18
pubmed: 28239471
Nat Neurosci. 2015 May;18(5):631-6
pubmed: 25803835
J Clin Invest. 1999 Jan;103(1):5-9
pubmed: 9884328
J Neurosci Res. 2011 May;89(5):718-28
pubmed: 21337372
PLoS One. 2012;7(4):e34640
pubmed: 22485182
J Neurosci. 2017 Apr 26;37(17):4493-4507
pubmed: 28336567
J Exp Med. 2010 Sep 27;207(10):2053-63
pubmed: 20837696
Nat Neurosci. 2017 Aug;20(8):1162-1171
pubmed: 28671693
Neuropathol Appl Neurobiol. 2013 Feb;39(1):19-34
pubmed: 23039106
Nat Med. 2013 Mar;19(3):313-21
pubmed: 23396211
Elife. 2019 Jul 16;8:
pubmed: 31309927
Trends Mol Med. 2016 Jun;22(6):511-527
pubmed: 27211305
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113
pubmed: 28977441
Front Aging Neurosci. 2018 Aug 06;10:236
pubmed: 30127734
Front Immunol. 2019 Apr 05;10:711
pubmed: 31024547
Autophagy. 2010 May;6(4):495-505
pubmed: 20404487
EMBO J. 2000 Sep 15;19(18):4976-85
pubmed: 10990461
Int J Mol Sci. 2017 Apr 05;18(4):
pubmed: 28379162
Nat Immunol. 2012 Nov;13(11):1101-9
pubmed: 23023393
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
Neuron. 2020 Jun 3;106(5):789-805.e5
pubmed: 32220666
Nat Neurosci. 2008 Apr;11(4):420-2
pubmed: 18344992
Acta Neuropathol Commun. 2015 May 23;3:31
pubmed: 26001565
Immunity. 2012 Aug 24;37(2):223-34
pubmed: 22921120
Science. 2011 Jul 8;333(6039):228-33
pubmed: 21617041
J Leukoc Biol. 2010 Dec;88(6):1171-80
pubmed: 20651301
Sci Signal. 2011 Aug 09;4(187):pe39
pubmed: 21868362
J Exp Med. 2019 Feb 4;216(2):267-278
pubmed: 30635357
Nat Commun. 2015 Jan 21;6:6074
pubmed: 25606824
Mol Cell. 2011 Feb 18;41(4):458-70
pubmed: 21329883
Autophagy. 2019 Oct;15(10):1719-1737
pubmed: 30939964
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Aging Dis. 2019 Apr 1;10(2):367-382
pubmed: 31011483
J Biol Chem. 2001 May 11;276(19):16223-31
pubmed: 11279107
Acta Neuropathol. 2015 Jul;130(1):77-92
pubmed: 25943890
J Exp Med. 2004 Jun 21;199(12):1641-50
pubmed: 15210742