Paeoniflorin-6'-o-benzene sulfonate (CP-25) improves vasculitis through inhibiting IL-17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats.
IL-17A
JAK/STAT3 signaling pathway
cardiovascular diseases
endothelial cell activation
paeoniflorin-6′-o-benzene sulfonate
rheumatoid arthritis
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
15
04
2020
revised:
13
08
2020
accepted:
21
08
2020
pubmed:
3
10
2020
medline:
31
3
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects not only joints but also multiple organ systems including cardiovascular system. Endothelial dysfunction plays an important role in cardiovascular diseases (CVD). In RA, endothelial dysfunction exists at both the macrovascular and the microvascular levels, which is a precursor to vasculitis. This study aimed to investigate the pathogenesis of vasculitis and the therapeutic effect of CP-25 on vasculitis in high-fat diet (HFD) collagen-induced arthritis (CIA) rats. Experimental groups were divided into normal group, HFD group, CIA group, HFD CIA group, CP-25 group and MTX group. In vitro, IL-17A was used to stimulate human umbilical vein endothelial cells (HUVECs), and then CP-25 was used to intervene. Results showed that CP-25 reduced global scoring (GS), arthritis index (AI), and swollen joint count (SJC) scores, improved histopathological score, reduced T cells percentage, and decreased IL-17A and ICAM-1 levels. Besides, CP-25 reduced the expression of p-STAT3 to normal levels in vascular of HFD CIA rats. In vitro, IL-17A promoted the expression of p-JAK1, p-JAK2, p-JAK3, pSTAT3, and ICAM-1, and CP-25 inhibited the expression of p-JAK1, p-JAK2, p-JAK3, p-STAT3, and ICAM-1. In conclusion, CP-25 might inhibit endothelial cell activation through inhibiting IL-17A/JAK/STAT3 signaling pathway, which improves vasculitis in HFD CIA rats.
Substances chimiques
Glucosides
0
Interleukin-17
0
Monoterpenes
0
paeoniflorin-6'-O-benzenesulfonate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1047Subventions
Organisme : National Natural Science Foundation of China
ID : No 81973332
Organisme : National Natural Science Foundation of China
ID : U1803129
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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