Pediatric Myocardial T1 and T2 Value Associations with Age and Heart Rate at 1.5 T.
Cardiac magnetic resonance
Native T1
Normal values
Pediatric
Tissue mapping
Journal
Pediatric cardiology
ISSN: 1432-1971
Titre abrégé: Pediatr Cardiol
Pays: United States
ID NLM: 8003849
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
23
07
2020
accepted:
26
09
2020
pubmed:
3
10
2020
medline:
5
5
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
The objective of the study was to determine normal global left ventricular reference values for T1 and T2 in children. This is a retrospective study that included healthy subjects, age 5-19 years, who underwent CMR for the indication of pectus excavatum from 2018 to 2019. Linear regression models were used to determine associations of native T1 and T2 values to heart rate, age, and other CMR parameters. 102 patients with a mean age of 14.0 ± 2.4 years were included (range 5.4-18.8). 87 (85%) were males and 15 (15%) were females. The mean global T1 was 1018 ± 25 ms and the mean T2 was 53 ± 3 ms. T1 was negatively correlated with age (r = - 0.39, p < 0.001) and positively correlated with heart rate (r = 0.32, p < 0.001) by univariate analysis. Multivariable analysis showed that age and heart rate were independently associated with T1. T2 demonstrated a weak negative correlation with age (r = - 0.20, p = 0.047) and no correlation with heart rate. There was no difference in T1 (p = 0.23) or T2 (p = 0.52) between genders. This study reports normal pediatric T1 and T2 values at a 1.5 Tesla scanner. T1 was dependent on age and heart rate, while T2 was less dependent on age with no correlation with heart rate.
Identifiants
pubmed: 33006645
doi: 10.1007/s00246-020-02479-9
pii: 10.1007/s00246-020-02479-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
269-277Références
Salerno M, Kramer CM (2013) Advances in parametric mapping with CMR imaging. JACC Cardiovasc Imaging 6:806–22
doi: 10.1016/j.jcmg.2013.05.005
Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S (2016) Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson 18:89
doi: 10.1186/s12968-016-0308-4
Ferreira VM, Schulz-Menger J, Holmvang G et al (2018) Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations. J Am Coll Cardiol 72:3158–76
doi: 10.1016/j.jacc.2018.09.072
Hales-Kharazmi A, Hirsch N, Kelleman M, Slesnick T, Deshpande SR (2018) Utility of cardiac MRI in paediatric myocarditis. Cardiol Young 28:377–85
doi: 10.1017/S1047951117001093
Yim D, Riesenkampff E, Caro-Dominguez P, Yoo SJ, Seed M, Grosse-Wortmann L (2017) Assessment of diffuse ventricular myocardial fibrosis using native T1 in children with repaired tetralogy of fallot. Circ Cardiovasc Imaging 10:e005695
doi: 10.1161/CIRCIMAGING.116.005695
Dusenbery SM, Jerosch-Herold M, Rickers C et al (2014) Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis. J Am Coll Cardiol 63:1778–85
doi: 10.1016/j.jacc.2013.11.066
Starc JJ, Moore RA, Rattan MS et al (2017) Elevated myocardial extracellular volume fraction in duchenne muscular dystrophy. Pediatric Cardiol 38:1485–92
doi: 10.1007/s00246-017-1690-x
Messroghli DR, Moon JC, Ferreira VM et al (2017) Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: a consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI). J Cardiovasc Magn Reson 19:75
doi: 10.1186/s12968-017-0389-8
Barczuk-Falecka M, Malek LA, Werys K, Roik D, Adamus K, Brzewski M (2019) Normal values of native T1 and T2 relaxation times on 3T cardiac MR in a healthy pediatric population aged 9–18 years. J Magn Reson Imaging 51(3):912–918
doi: 10.1002/jmri.26886
Dabir D, Child N, Kalra A et al (2014) Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 16:69
doi: 10.1186/s12968-014-0069-x
Liu JM, Liu A, Leal J et al (2017) Measurement of myocardial native T1 in cardiovascular diseases and norm in 1291 subjects. J Cardiovasc Magn Reson 19:74
doi: 10.1186/s12968-017-0386-y
Rosmini S, Bulluck H, Captur G et al (2018) Myocardial native T1 and extracellular volume with healthy ageing and gender. Eur Heart J Cardiovasc Imaging 19:615–21
doi: 10.1093/ehjci/jey034
Birkemeier KL, Podberesky DJ, Salisbury S, Serai S (2012) Limited, fast magnetic resonance imaging as an alternative for preoperative evaluation of pectus excavatum: a feasibility study. J Thorac Imaging 27:393–7
doi: 10.1097/RTI.0b013e31822da1b6
Saleh RS, Finn JP, Fenchel M et al (2010) Cardiovascular magnetic resonance in patients with pectus excavatum compared with normal controls. J Cardiovasc Magn Reson 12:73
doi: 10.1186/1532-429X-12-73
Pradella S, Grazzini G, Brandani M et al (2019) Cardiac magnetic resonance in patients with mitral valve prolapse: focus on late gadolinium enhancement and T1 mapping. Eur Radiol 29:1546–54
doi: 10.1007/s00330-018-5634-5
Kellman P, Hansen MS (2014) T1-mapping in the heart: accuracy and precision. J Cardiovasc Magn Reson 16:2
doi: 10.1186/1532-429X-16-2
Fernandez-Jimenez R, Sanchez-Gonzalez J, Aguero J et al (2015) Fast T2 gradient-spin-echo (T2-GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion. J Cardiovasc Magn Reson 17:92
doi: 10.1186/s12968-015-0199-9
Alsaied T, Sleeper LA, Masci M et al (2018) Maldistribution of pulmonary blood flow in patients after the Fontan operation is associated with worse exercise capacity. J Cardiovasc Magn Reson 20:85
doi: 10.1186/s12968-018-0505-4
Liu CY, Liu YC, Wu C et al (2013) Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 62:1280–7
doi: 10.1016/j.jacc.2013.05.078
Roy C, Slimani A, de Meester C et al (2017) Age and sex corrected normal reference values of T1, T2 T2* and ECV in healthy subjects at 3T CMR. J Cardiovasc Magn Reson 19:72
doi: 10.1186/s12968-017-0371-5
Burkhardt BEU, Menghini C, Rucker B, Kellenberger CJ, Valsangiacomo Buechel ER (2020) Normal myocardial native T1 values in children using single-point saturation recovery and modified look-locker inversion recovery (MOLLI). J Magn Reson Imaging 51:897–903
doi: 10.1002/jmri.26910
Piechnik SK, Ferreira VM, Lewandowski AJ et al (2013) Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI. J Cardiovasc Magn Reson 15:13
doi: 10.1186/1532-429X-15-13
Granitz M, Motloch LJ, Granitz C et al (2019) Comparison of native myocardial T1 and T2 mapping at 1.5T and 3T in healthy volunteers : reference values and clinical implications. Wien Klin Wochenschr 131:143–55
doi: 10.1007/s00508-018-1411-3
Teixeira T, Hafyane T, Stikov N, Akdeniz C, Greiser A, Friedrich MG (2016) Comparison of different cardiovascular magnetic resonance sequences for native myocardial T1 mapping at 3T. J Cardiovasc Magn Reson 18:65
doi: 10.1186/s12968-016-0286-6
Gottbrecht M, Kramer CM, Salerno M (2019) Native T1 and extracellular volume measurements by cardiac MRI in healthy adults: a meta-analysis. Radiology 290:317–26
doi: 10.1148/radiol.2018180226
Kilicgun A, Yaksi O, Unal M (2019) Is pectus excavatum a risk factor for spontaneous pneumothorax? “Haller index measurements in patients with primary spontaneous pneumothorax”. Can Respir J 2019:3291628
doi: 10.1155/2019/3291628
Cornicelli MD, Rigsby CK, Rychlik K, Pahl E, Robinson JD (2019) Diagnostic performance of cardiovascular magnetic resonance native T1 and T2 mapping in pediatric patients with acute myocarditis. J Cardiovasc Magn Reson 21:40
doi: 10.1186/s12968-019-0550-7
Robson MD, Piechnik SK, Tunnicliffe EM, Neubauer S (2013) T1 measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences. Magn Reson Med 70:664–70
doi: 10.1002/mrm.24867