Increased risk of IRIS-associated tuberculosis in HIV-infected patients receiving Integrase Inhibitors.
Adult
Aged
Antiretroviral Therapy, Highly Active
/ adverse effects
Female
HIV Infections
/ drug therapy
Humans
Immune Reconstitution Inflammatory Syndrome
/ epidemiology
Incidence
Integrase Inhibitors
/ adverse effects
Logistic Models
Male
Middle Aged
Multivariate Analysis
Retrospective Studies
Tuberculosis
/ epidemiology
Young Adult
HIV
INSTI
IRIS-associated tuberculosis
Integrase inhibitors
Journal
Infectious diseases now
ISSN: 2666-9919
Titre abrégé: Infect Dis Now
Pays: France
ID NLM: 101775152
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
28
02
2020
accepted:
21
09
2020
pubmed:
3
10
2020
medline:
8
9
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
Tuberculosis is associated with a risk of immune reconstitution inflammatory syndrome (IRIS) after ART initiation. Data from all patients with newly diagnosed tuberculosis disease and uncontrolled HIV infection from 1997 to 2017 in a French center were retrospectively collected. We evaluated the incidence of tuberculosis-IRIS in patients initiating ART with or without integrase inhibitors (INSTI) RESULTS: Fifty-five patients were included: 21 receiving an INSTI regimen and 34 a non-INSTI regimen. Except with regard to ART regimen, the two groups were comparable (median CD4 of 85/mm
Sections du résumé
BACKGROUND
Tuberculosis is associated with a risk of immune reconstitution inflammatory syndrome (IRIS) after ART initiation.
METHODS
Data from all patients with newly diagnosed tuberculosis disease and uncontrolled HIV infection from 1997 to 2017 in a French center were retrospectively collected. We evaluated the incidence of tuberculosis-IRIS in patients initiating ART with or without integrase inhibitors (INSTI) RESULTS: Fifty-five patients were included: 21 receiving an INSTI regimen and 34 a non-INSTI regimen. Except with regard to ART regimen, the two groups were comparable (median CD4 of 85/mm
Identifiants
pubmed: 33007401
pii: S0399-077X(20)30703-4
doi: 10.1016/j.medmal.2020.09.005
pii:
doi:
Substances chimiques
Integrase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-93Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.