Biological evidence of gintonin efficacy in memory disorders.
Agonist
Gintonin
Glycolipoprotein
LPARs
Memory disorders
Neuroprotection
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
01
07
2020
revised:
27
08
2020
accepted:
22
09
2020
pubmed:
3
10
2020
medline:
18
11
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
Gintonin is a novel glycolipoprotein, which has been abundantly found in the root of Korean ginseng. It holds lysophosphatidic acids (LPAs), primarily identified LPA C18:2, and is an exogenous agonist of LPA receptors (LPARs). Gintonin maintains blood-brain barrier integrity, and it has recently been studied in several models of neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. Gintonin demonstrated neuroprotective activity by providing action against neuroinflammation-, apoptosis- and oxidative stress-mediated neurodegeneration. Gintonin showed an emerging role as a modulator of synaptic transmission and neurogenesis and also potentially regulated autophagy in primary cortical astrocytes. It also ameliorated the toxic agent-induced and genetic models of cognitive deficits in experimental NDDs. As a novel agonist of LPARs, gintonin regulated several G protein-coupled receptors (GPCRs) including GPR40 and GPR55. However, further study needs to be investigated to understand the underlying mechanism of action of gintonin in memory disorders.
Identifiants
pubmed: 33007419
pii: S1043-6618(20)31529-2
doi: 10.1016/j.phrs.2020.105221
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Plant Extracts
0
gintonin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105221Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.