Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.
Adolescent
Adult
Aged
Antioxidants
/ adverse effects
Biomarkers
/ metabolism
Catalase
/ metabolism
Child
Dietary Supplements
/ adverse effects
Female
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Glutathione Reductase
/ metabolism
Humans
Lipid Peroxidation
/ drug effects
Male
Malondialdehyde
/ metabolism
Melatonin
/ adverse effects
Middle Aged
Nitric Oxide
/ metabolism
Oxidative Stress
/ drug effects
Randomized Controlled Trials as Topic
Superoxide Dismutase
/ metabolism
Treatment Outcome
Young Adult
Glutathione
Malondialdehyde
Melatonin
Oxidative stress
Total antioxidant capacity
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
04
08
2020
revised:
11
09
2020
accepted:
15
09
2020
pubmed:
3
10
2020
medline:
2
9
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties. To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials. A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 % confidence intervals (CI). Cochrane's Q and I A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 % CI: 0.30, 1.21; I Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types.
Sections du résumé
BACKGROUND
Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties.
OBJECTIVE
To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials.
METHODS
A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 % confidence intervals (CI). Cochrane's Q and I
RESULTS
A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 % CI: 0.30, 1.21; I
CONCLUSION
Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types.
Identifiants
pubmed: 33007423
pii: S1043-6618(20)31518-8
doi: 10.1016/j.phrs.2020.105210
pii:
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Nitric Oxide
31C4KY9ESH
Malondialdehyde
4Y8F71G49Q
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Glutathione Reductase
EC 1.8.1.7
Glutathione
GAN16C9B8O
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105210Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.