Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer.
antibodies
cancer
carbohydrate
glycosylation
nanoparticle
nanoprint
polymer
tumor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Sep 2020
30 Sep 2020
Historique:
received:
08
09
2020
revised:
28
09
2020
accepted:
28
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
4
10
2020
Statut:
epublish
Résumé
Glycosylation patterns commonly change in cancer, resulting in expression of tumor-associated carbohydrate antigens (TACA). While promising, currently available anti-glycan antibodies are not useful for clinical cancer therapy. Here, we show that potent anti-glycan antibodies can be engineered to acquire cancer therapeutic efficacy. We designed yeast surface display to generate and select for therapeutic antibodies against the TACA SLe
Identifiants
pubmed: 33007970
pii: cancers12102824
doi: 10.3390/cancers12102824
pmc: PMC7601599
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Research Council
ID : ERC-2016-STG-716220
Pays : International
Organisme : NIH HHS
ID : U01GM120419
Pays : United States
Organisme : UC Davis - Israel Collaborations in Research
ID : 2019
Organisme : Science Builds the Nation scholarship of The Israeli Prime Minister's Office
ID : 2019
Organisme : The Israeli Scholarship Education Foundation
ID : 2019
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