Heteromerization of Endogenous Mu and Delta Opioid Receptors Induces Ligand-Selective Co-Targeting to Lysosomes.
delta opioid receptor
heteromer
internalization
lysosomes
mu opioid receptor
primary hippocampal culture
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
30 Sep 2020
30 Sep 2020
Historique:
received:
30
07
2020
revised:
23
09
2020
accepted:
29
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Increasing evidence indicates that native mu and delta opioid receptors can associate to form heteromers in discrete brain neuronal circuits. However, little is known about their signaling and trafficking. Using double-fluorescent knock-in mice, we investigated the impact of neuronal co-expression on the internalization profile of mu and delta opioid receptors in primary hippocampal cultures. We established ligand selective mu-delta co-internalization upon activation by 1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-4-piperidinecarboxylic acid, ethyl ester (CYM51010), [d-Ala2, NMe-Phe4, Gly-ol5]enkephalin (DAMGO), and deltorphin II, but not (+)-4-[(α
Identifiants
pubmed: 33007971
pii: molecules25194493
doi: 10.3390/molecules25194493
pmc: PMC7583997
pii:
doi:
Substances chimiques
CYM51010
0
Ligands
0
Piperidines
0
Receptors, Opioid, delta
0
Receptors, Opioid, mu
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation pour la Recherche Médicale
ID : DPA20140129364
Organisme : IDEX UNiversity of Strasbourg
ID : postdoctoral fellowship
Organisme : Centre national de la Recherche Scientifique
ID : na
Organisme : University of Strasbourg
ID : na
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