Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium.
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ genetics
Brain
/ metabolism
Choroid Plexus
/ growth & development
Epithelial Cells
/ metabolism
Epithelium
/ metabolism
Fructose
/ metabolism
Glucose
/ metabolism
Glucose Transport Proteins, Facilitative
/ genetics
Glucose Transporter Type 1
/ genetics
Humans
Neoplasm Proteins
/ genetics
Organic Anion Transporters
/ genetics
Organic Cation Transport Proteins
/ genetics
Sodium-Glucose Transporter 1
/ genetics
Uric Acid
/ metabolism
BCRP/ABCG2
GLUT
SGLT
URAT1
aging
blood-cerebrospinal fluid barrier
cell polarity
metabolism
neurodegenerative diseases
renal proximal tubule
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Sep 2020
30 Sep 2020
Historique:
received:
26
08
2020
revised:
25
09
2020
accepted:
28
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
24
2
2021
Statut:
epublish
Résumé
The choroid plexus plays a central role in the regulation of the microenvironment of the central nervous system by secreting the majority of the cerebrospinal fluid and controlling its composition, despite that it only represents approximately 1% of the total brain weight. In addition to a variety of transporter and channel proteins for solutes and water, the choroid plexus epithelial cells are equipped with glucose, fructose, and urate transporters that are used as energy sources or antioxidative neuroprotective substrates. This review focuses on the recent advances in the understanding of the transporters of the SLC2A and SLC5A families (GLUT1, SGLT2, GLUT5, GLUT8, and GLUT9), as well as on the urate-transporting URAT1 and BCRP/ABCG2, which are expressed in choroid plexus epithelial cells. The glucose, fructose, and urate transporters repertoire in the choroid plexus epithelium share similar features with the renal proximal tubular epithelium, although some of these transporters exhibit inversely polarized submembrane localization. Since choroid plexus epithelial cells have high energy demands for proper functioning, a decline in the expression and function of these transporters can contribute to the process of age-associated brain impairment and pathophysiology of neurodegenerative diseases.
Identifiants
pubmed: 33008107
pii: ijms21197230
doi: 10.3390/ijms21197230
pmc: PMC7582461
pii:
doi:
Substances chimiques
ABCG2 protein, human
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Glucose Transport Proteins, Facilitative
0
Glucose Transporter Type 1
0
Neoplasm Proteins
0
Organic Anion Transporters
0
Organic Cation Transport Proteins
0
SLC22A12 protein, human
0
SLC2A1 protein, human
0
Sodium-Glucose Transporter 1
0
Uric Acid
268B43MJ25
Fructose
30237-26-4
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17K08788, 17K15896, 19K07508, 20K16193
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