Antiviral effect of baicalin on Marek's disease virus in CEF cells.
Antiviral activity
Baicalin
Inhibition
Marek’s disease virus
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
02 Oct 2020
02 Oct 2020
Historique:
received:
01
06
2020
accepted:
28
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
4
5
2021
Statut:
epublish
Résumé
Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek's disease virus (MDV) activities of baicalin in CEF cells. Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs. These results demonstrate that baicalin could be a potential drug against MDV infection.
Sections du résumé
BACKGROUND
BACKGROUND
Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek's disease virus (MDV) activities of baicalin in CEF cells.
RESULTS
RESULTS
Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs.
CONCLUSIONS
CONCLUSIONS
These results demonstrate that baicalin could be a potential drug against MDV infection.
Identifiants
pubmed: 33008383
doi: 10.1186/s12917-020-02595-x
pii: 10.1186/s12917-020-02595-x
pmc: PMC7532598
doi:
Substances chimiques
Antiviral Agents
0
Cytokines
0
Flavonoids
0
RNA, Messenger
0
baicalin
347Q89U4M5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
371Subventions
Organisme : Key Program of NSFC-Henan Joint Fund
ID : U1604232
Organisme : National key research and development program
ID : 2017YFD0500702
Organisme : National Natural Science Foundation of China
ID : 31772734
Organisme : National Natural Science Foundation of China
ID : 31972717
Organisme : NCFC-RCUK-BBSRC
ID : 31761133002
Organisme : Biological Sciences Research Council (BBSRC) grant
ID : BB/R007896/1
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