Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
4
10
2020
medline:
5
1
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone. Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations. In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients. Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).
Identifiants
pubmed: 33009060
doi: 10.14309/ajg.0000000000000957
pmc: PMC7710608
mid: NIHMS1625262
pii: 00000434-202012000-00030
doi:
Banques de données
ClinicalTrials.gov
['NCT02019758']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2098-2102Subventions
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101856
Pays : United States
Références
United European Gastroenterol J. 2017 Apr;5(3):335-358
pubmed: 28507746
Dig Dis Sci. 2010 Jul;55(7):1940-9
pubmed: 19830560
Gastroenterology. 2014 Dec;147(6):1255-66.e21
pubmed: 25160980
Gastrointest Endosc. 2017 Oct;86(4):581-591.e3
pubmed: 28461094
Gut. 2013 Apr;62(4):489-95
pubmed: 22619364
Gastroenterology. 2019 Jul;157(1):65-73.e5
pubmed: 30872104
Am J Gastroenterol. 2016 Feb;111(2):206-13
pubmed: 26753894
Am J Gastroenterol. 2013 May;108(5):679-92; quiz 693
pubmed: 23567357
Aliment Pharmacol Ther. 2013 Sep;38(6):634-42
pubmed: 23837796
Clin Gastroenterol Hepatol. 2019 Oct;17(11):2149-2160
pubmed: 30710696
Am J Gastroenterol. 2010 May;105(5):1062-70
pubmed: 19935783
Clin Gastroenterol Hepatol. 2016 Jan;14(1):31-9
pubmed: 26404868
Dis Esophagus. 2017 Jul 1;30(7):1-7
pubmed: 29206905