Late Ventilator-Induced Diaphragmatic Dysfunction After Extubation.
Journal
Critical care medicine
ISSN: 1530-0293
Titre abrégé: Crit Care Med
Pays: United States
ID NLM: 0355501
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
4
10
2020
medline:
28
5
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
Mechanical ventilation is associated with primary diaphragmatic dysfunction, also termed ventilator-induced diaphragmatic dysfunction. Studies evaluating diaphragmatic function recovery after extubation are lacking. We evaluated early and late recoveries from ventilator-induced diaphragmatic dysfunction in a mouse model. Experimental randomized study. Research laboratory. C57/BL6 mice. Six groups of C57/BL6 mice. Mice were ventilated for 6 hours and then euthanatized immediately (n = 18), or 1 (n = 18) or 10 days after extubation with (n = 5) and without S107 (n = 16) treatment. Mice euthanatized immediately after 6 hours of anesthesia (n = 15) or after 6 hours of anesthesia and 10 days of recovery (n = 5) served as controls. For each group, diaphragm force production, posttranslational modification of ryanodine receptor, oxidative stress, proteolysis, and cross-sectional areas were evaluated. After 6 hours of mechanical ventilation, diaphragm force production was decreased by 25-30%, restored to the control levels 1 day after extubation, and secondarily decreased by 20% 10 days after extubation compared with controls. Ryanodine receptor was protein kinase A-hyperphosphorylated, S-nitrosylated, oxidized, and depleted of its stabilizing subunit calstabin-1 6 hours after the onset of the mechanical ventilation, 1 and 10 days after extubation. Post extubation treatment with S107, a Rycal drug that stabilizes the ryanodine complex, did reverse the loss of diaphragmatic force associated with mechanical ventilation. Total protein oxidation was restored to the control levels 1 day after extubation. Markers of proteolysis including calpain 1 and calpain 2 remained activated 10 days after extubation without significant changes in cross-sectional areas. We report that mechanical ventilation is associated with a late diaphragmatic dysfunction related to a structural alteration of the ryanodine complex that is reversed with the S107 treatment.
Identifiants
pubmed: 33009102
doi: 10.1097/CCM.0000000000004569
pii: 00003246-202012000-00062
doi:
Substances chimiques
Ryanodine Receptor Calcium Release Channel
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1300-e1305Références
Demoule A, Jung B, Prodanovic H, et al. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;188:213–219.
Supinski GS, Callahan LA. Diaphragm weakness in mechanically ventilated critically ill patients. Crit Care. 2013;17:R120.
Dres M, Dubé BP, Mayaux J, et al. Coexistence and impact of limb muscle and diaphragm weakness at time of liberation from mechanical ventilation in medical intensive care unit patients. Am J Respir Crit Care Med. 2017;195:57–66.
Jung B, Moury PH, Mahul M, et al. Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure. Intensive Care Med. 2016;42:853–861.
Dres M, Schmidt M, Ferre A, et al. Diaphragm electromyographic activity as a predictor of weaning failure. Intensive Care Med. 2012;38:2017–2025.
Demoule A, Molinari N, Jung B, et al. Patterns of diaphragm function in critically ill patients receiving prolonged mechanical ventilation: A prospective longitudinal study. Ann Intensive Care. 2016;6:75.
Mrozek S, Jung B, Petrof BJ, et al. Rapid onset of specific diaphragm weakness in a healthy murine model of ventilator-induced diaphragmatic dysfunction. Anesthesiology. 2012;117:560–567.
Matecki S, Dridi H, Jung B, et al. Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proc Natl Acad Sci U S A. 2016;113:9069–9074.
Thomas D, Maes K, Agten A, et al. Time course of diaphragm function recovery after controlled mechanical ventilation in rats. J Appl Physiol (1985). 2013;115:775–784.
Jaber S, Petrof BJ, Jung B, et al. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med. 2011;183:364–371.
Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med. 2004;169:336–341.
Picard M, Jung B, Liang F, et al. Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation. Am J Respir Crit Care Med. 2012;186:1140–1149.
Hussain SN, Mofarrahi M, Sigala I, et al. Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med. 2010;182:1377–1386.
Levine S, Nguyen T, Taylor N, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008;358:1327–1335.
Powers SK, Kavazis AN, Levine S. Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med. 2009;37:S347–S353.
Dridi H, Yehya M, Barsotti R, et al. Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation. Free Radic Biol Med. 2020;146:383–391.
van den Berg M, Hooijman PE, Beishuizen A, et al. Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med. 2017;196:1544–1558.
Goligher EC, Fan E, Herridge MS, et al. Evolution of diaphragm thickness during mechanical ventilation. Impact of inspiratory effort. Am J Respir Crit Care Med. 2015;192:1080–1088.
Kim WY, Suh HJ, Hong SB, et al. Diaphragm dysfunction assessed by ultrasonography: Influence on weaning from mechanical ventilation. Crit Care Med. 2011;39:2627–2630.
Bruells CS, Bergs I, Rossaint R, et al. Recovery of diaphragm function following mechanical ventilation in a rodent model. PLoS One. 2014;9:e87460.
Yoshihara T, Ichinoseki-Sekine N, Kakigi R, et al. Repeated exposure to heat stress results in a diaphragm phenotype that resists ventilator-induced diaphragm dysfunction. J Appl Physiol (1985). 2015;119:1023–1031.
Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1–222.
Jung B, Constantin JM, Rossel N, et al. Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction in piglet: An in vivo and in vitro study. Anesthesiology. 2010;112:1435–1443.
Thille AW, Boissier F, Ben Ghezala H, et al. Risk factors for and prediction by caregivers of extubation failure in ICU patients: A prospective study. Crit Care Med. 2015;43:613–620.
Ruan SY, Teng NC, Wu HD, et al. Durability of weaning success for liberation from invasive mechanical ventilation: An analysis of a nationwide database. Am J Respir Crit Care Med. 2017;196:792–795.
Thille AW, Richard JC, Brochard L. The decision to extubate in the intensive care unit. Am J Respir Crit Care Med. 2013;187:1294–1302.
Jaber S, Jung B, Matecki S, et al. Clinical review: Ventilator-induced diaphragmatic dysfunction–human studies confirm animal model findings!. Crit Care. 2011;15:206.
Yang L, Luo J, Bourdon J, et al. Controlled mechanical ventilation leads to remodeling of the rat diaphragm. Am J Respir Crit Care Med. 2002;166:1135–1140.
DiNino E, Gartman EJ, Sethi JM, et al. Diaphragm ultrasound as a predictor of successful extubation from mechanical ventilation. Thorax. 2014;69:423–427.
Reiken S, Lacampagne A, Zhou H, et al. PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: Defective regulation in heart failure. J Cell Biol. 2003;160:919–928.
Bellinger AM, Reiken S, Carlson C, et al. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med. 2009;15:325–330.
Andersson DC, Betzenhauser MJ, Reiken S, et al. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab. 2011;14:196–207.
Bellinger AM, Reiken S, Carlson C, et al. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med. 2009;15:325–330.
Bellinger AM, Mongillo M, Marks AR. Stressed out: The skeletal muscle ryanodine receptor as a target of stress. J Clin Invest. 2008;118:445–453.
Jaber S, Sebbane M, Koechlin C, et al. Effects of short vs. prolonged mechanical ventilation on antioxidant systems in piglet diaphragm. Intensive Care Med. 2005;31:1427–1433.
Kavazis AN, Talbert EE, Smuder AJ, et al. Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production. Free Radic Biol Med. 2009;46:842–850.
McClung JM, Kavazis AN, Whidden MA, et al. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. J Physiol. 2007;585:203–215.
Powers SK, Wiggs MP, Sollanek KJ, et al. Ventilator-induced diaphragm dysfunction: Cause and effect. Am J Physiol Regul Integr Comp Physiol. 2013;305:R464–R477.
Ye T, Wang Q, Zhang Y, et al. Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling. PLoS One. 2015;10:e0120178.
Wan F, Letavernier E, Le Saux CJ, et al. Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation. Am J Physiol Heart Circ Physiol. 2015;309:H1883–H1893.
Parks RJ, Murphy E, Liu JC. Mitochondrial permeability transition pore and calcium handling. Methods Mol Biol. 2018;1782:187–196.
Jung B, Nougaret S, Conseil M, et al. Sepsis is associated with a preferential diaphragmatic atrophy: A critically ill patient study using tridimensional computed tomography. Anesthesiology. 2014;120:1182–1191.
Sieck GC, Ferreira LF, Reid MB, et al. Mechanical properties of respiratory muscles. Compr Physiol. 2013;3:1553–1567.