Relationship of Bladder Pain With Clinical and Urinary Markers of Neuroinflammation in Women With Urinary Urgency Without Urinary Incontinence.
Adult
Biomarkers
/ urine
Brain-Derived Neurotrophic Factor
/ urine
Cross-Sectional Studies
Cystitis, Interstitial
/ diagnosis
Female
Humans
Middle Aged
Nerve Growth Factor
/ urine
Neuroinflammatory Diseases
/ diagnosis
Osteopontin
/ urine
Prospective Studies
Severity of Illness Index
Vascular Endothelial Growth Factor A
/ urine
Visual Analog Scale
Journal
Female pelvic medicine & reconstructive surgery
ISSN: 2154-4212
Titre abrégé: Female Pelvic Med Reconstr Surg
Pays: United States
ID NLM: 101528690
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
4
10
2020
medline:
15
12
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
The pathogenesis of bladder pain is poorly understood. Our hypothesis is that in women with urinary urgency without incontinence, bladder pain is associated with the presence of neurogenic inflammation in the bladder wall and neuroinflammatory biomarkers in the urine. We conducted a prospective cross-sectional study of women with urinary urgency without incontinence. Urinary symptoms were measured using Female Genitourinary Pain Index. Neuropathic pain, a clinical biomarker of neuroinflammation, was measured using the PainDETECT questionnaire. Inflammatory neuropeptides measured in the urine included nerve growth factor (NGF), brain-derived neurotrophic factor, vascular endothelial growth factor, and osteopontin. Neuropathic pain scores and urinary neuropeptide levels were compared between patients with and without bladder pain using univariable and multivariable analyses. In 101 women with urinary urgency without incontinence, 62 (61%) were in the bladder pain group (visual analog scale score, ≤ 3), whereas 39 (39%) were in the no bladder pain group. Urinary symptom scores (5.0 ± 3.1 versus 3.5 ± 2.4, P < 0.001) and neuropathic pain scores (13.3 ± 8.6 vs 5.1 ± 4.8, P < 0.001) were significantly higher for the bladder pain group than for the no bladder pain group. On multivariable analysis after controlling for age, body mass index, and severity of urinary urgency, bladder pain score was significantly associated with elevated urinary levels of vascular endothelial growth factor (P = 0.04) and osteopontin (P = 0.02), whereas the neuropathic pain score was significantly associated with an increased NGF level (P = 0.03). In women with urinary urgency without incontinence, bladder pain is associated with the presence of clinical and urinary biomarkers of neuroinflammation.
Identifiants
pubmed: 33009262
pii: 01436319-202102000-00042
doi: 10.1097/SPV.0000000000000951
pmc: PMC7854944
mid: NIHMS1614985
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
NGF protein, human
0
Vascular Endothelial Growth Factor A
0
Osteopontin
106441-73-0
Nerve Growth Factor
9061-61-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e418-e422Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK116648
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121506
Pays : United States
Informations de copyright
Copyright © 2020 American Urogynecologic Society. All rights reserved.
Déclaration de conflit d'intérêts
The authors have declared they have no conflicts of interest.
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