Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
02 10 2020
02 10 2020
Historique:
received:
24
04
2020
accepted:
21
09
2020
entrez:
3
10
2020
pubmed:
4
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn population-based controls. These 33,872 cohort members were genotyped on the Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated the polygenic risk score (PRS) for ADHD and extracted register data regarding the following risk factors pertaining to the psychosocial environment for each cohort member at the time of birth: maternal/paternal history of mental disorders, maternal/paternal education, maternal/paternal work status, and maternal/paternal income. We used logistic regression analyses to assess the main effects of the PRS for ADHD and the psychosocial environment on the risk of ADHD. Subsequently, we evaluated whether the effect of the PRS and the psychosocial environment act independently or in interaction upon the risk of ADHD. We found that ADHD was strongly associated with the PRS (odds ratio: 6.03, 95%CI: 4.74-7.70 for highest vs. lowest 2% liability). All risk factors pertaining to the psychosocial environment were associated with an increased risk of ADHD. These associations were only slightly attenuated after mutual adjustments. We found no statistically significant interaction between the polygenic liability and the psychosocial environment upon the risk of ADHD. In conclusion, we found main effects of both polygenic liability and risk factors pertaining to the psychosocial environment on the risk of ADHD-in the expected direction.
Identifiants
pubmed: 33009369
doi: 10.1038/s41398-020-01019-6
pii: 10.1038/s41398-020-01019-6
pmc: PMC7532146
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
335Subventions
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R165-2013-15320, R102-A9118, R155-2014-1724 and R248-2017-2003
Pays : International
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