New frontiers in translational research: Touchscreens, open science, and the mouse translational research accelerator platform.
circuits
cognition
collaboration
community building
data sharing
knowledge sharing
mouse models
neurodegenerative disease
neuropsychiatric disease
neurotechnology
open science
reproducibility
standardization
touchscreens
translation
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
07
2020
revised:
03
09
2020
accepted:
29
09
2020
pubmed:
4
10
2020
medline:
4
1
2022
entrez:
3
10
2020
Statut:
ppublish
Résumé
Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in high-level cognitive functions including memory, attention, motivation, and decision-making. Despite several decades of extensive research, neuroscience is little closer to discovering new treatments. Key impediments include the absence of validated and robust cognitive assessment tools for facilitating translation from animal models to humans. In this review, we describe a state-of-the-art platform poised to overcome these impediments and improve the success of translational research, the Mouse Translational Research Accelerator Platform (MouseTRAP), which is centered on the touchscreen cognitive testing system for rodents. It integrates touchscreen-based tests of high-level cognitive assessment with state-of-the art neurotechnology to record and manipulate molecular and circuit level activity in vivo in animal models during human-relevant cognitive performance. The platform also is integrated with two Open Science platforms designed to facilitate knowledge and data-sharing practices within the rodent touchscreen community, touchscreencognition.org and mousebytes.ca. Touchscreencognition.org includes the Wall, showcasing touchscreen news and publications, the Forum, for community discussion, and Training, which includes courses, videos, SOPs, and symposia. To get started, interested researchers simply create user accounts. We describe the origins of the touchscreen testing system, the novel lines of research it has facilitated, and its increasingly widespread use in translational research, which is attributable in part to knowledge-sharing efforts over the past decade. We then identify the unique features of MouseTRAP that stand to potentially revolutionize translational research, and describe new initiatives to partner with similar platforms such as McGill's M3 platform (m3platform.org).
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12705Informations de copyright
© 2020 International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.
Références
International Brain Laboratory. An international laboratory for systems and computational neuroscience. Neuron. 2017;96(6):1213-1218. https://doi.org/10.1016/j.neuron.2017.12.013.
Carter CS, Barch DM. Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative. Schizophr Bull. 2007;33(5):1131-1137. https://doi.org/10.1093/schbul/sbm081.
Moore H, Geyer MA, Carter CS, Barch DM. Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models. Neurosci Biobehav Rev. 2013;37(9 Pt B):2087-2091. https://doi.org/10.1016/j.neubiorev.2013.09.011.
Stensbøl TB, Kapur S. NEWMEDS special issue commentary. Psychopharmacology (Berl). 2015;232(21-22):3849-3851. https://doi.org/10.1007/s00213-015-4083-y.
Hodes RJ, Insel TR, Landis SC. NIH blueprint for neuroscience research. The NIH toolbox: setting a standard for biomedical research. Neurology. 2013;80(11):S1. https://doi.org/10.1212/WNL.0b013e3182872e90.
Weintraub S, Dikmen SS, Heaton RK, et al. Cognition assessment using the NIH toolbox. Neurology. 2013;80(11):S54-S64. https://doi.org/10.1212/WNL.0b013e3182872ded.
Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167(7):748-751. https://doi.org/10.1176/appi.ajp.2010.09091379.
Cuthbert BN, Kozak MJ. Constructing constructs for psychopathology: the nimh research domain criteria. J Abnorm Psychol. 2013;122(3):928-937. https://doi.org/10.1037/a0034028.
Hvoslef-Eide M, Nilsson S, Saksida L, Bussey T. Cognitive translation using the rodent touchscreen testing approach. Curr Topics Behav Neurosci. 2016;28:423-447.
Barch D, Carter C, Arnsten A, et al. Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophr Bull. 2009;35(1):109-114.
Brooks S, Dunnett S. Tests to assess motor phenotype in mice: a user's guide. Nat Rev Neurosci. 2009;10:519-529.
Churchland PS, Sejnowski TJ. Perspectives on cognitive neuroscience. Science. 1988;242(4879):741-745. https://doi.org/10.1126/science.3055294.
Weiskrantz L. Trying to bridge some neuropsychological gaps between monkey and man. Br J Psychol. 1977;68(4):431-445. https://doi.org/10.1111/j.2044-8295.1977.tb01609.x.
Roberts A, Sahakian B. Comparable tests of cognitive function in monkey and man. A. Saghal (Ed.), Behavioural Neuroscience: A Practical Approach. Vol 1. Oxford, England: Oxford University Press; 1993:165-184.
Sahakian BJ, Owen AM. Computerized assessment in neuropsychiatry using CANTAB: discussion paper. J R Soc Med. 1992;85(7):399-402.
Fray P, Robbins T, Sahakian B. Neuropsychiatric applications of CANTAB. Intl J Geriatric Psychiatry. 1996;11:329-336.
Morris RG, Downes JJ, Sahakian BJ, Evenden JL, Heald A, Robbins TW. Planning and spatial working memory in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988;51(6):757-766. https://doi.org/10.1136/jnnp.51.6.757.
Sahakian BJ, Morris RG, Evenden JL, et al. A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain. 1988;111(Pt 3):695-718. https://doi.org/10.1093/brain/111.3.695.
Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P. Cambridge neuropsychological test automated battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia. 1994;5(5):266-281. https://doi.org/10.1159/000106735.
Klingberg T, Fernell E, Olesen PJ, et al. Computerized training of working memory in children with ADHD-a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry. 2005;44(2):177-186. https://doi.org/10.1097/00004583-200502000-00010.
Chacko A, Bedard AC, Marks DJ, et al. A randomized clinical trial of Cogmed working memory training in school-age children with ADHD: a replication in a diverse sample using a control condition. J Child Psychol Psychiatry. 2014;55(3):247-255. https://doi.org/10.1111/jcpp.12146.
Bussey T, Muir J, Robbins T. A novel automated touchscreen procedure for assessing learning in the rat using computer graphic stimuli. Neuroscience Res Communications. 1994;15(2):103-110.
Sahgal A, Steckler T. TouchWindows and operant behaviour in rats. J Neurosci Methods. 1994;55(1):59-64. https://doi.org/10.1016/0165-0270(94)90041-8.
Bussey TJ, Saksida LM, Rothblat LA. Discrimination of computer-graphic stimuli by mice: a method for the behavioral characterization of transgenic and gene-knockout models. Behav Neurosci. 2001;115(4):957-960. https://doi.org/10.1037//0735-7044.115.4.957.
Bussey TJ, Holmes A, Lyon L, et al. New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats. Neuropharmacology. 2012;62(3):1191-1203. https://doi.org/10.1016/j.neuropharm.2011.04.011.
Juczewski K, Koussa J, Kesner A, Lee J, Lovinger D. Stress and behavioral correlates in the head-fixed method doi: https://doi.org/10.1101/2020.02.24.963371
Iivonen H, Nurminen L, Harri M, Tanila H, Puoliväli J. Hypothermia in mice tested in Morris water maze. Behav Brain Res. 2003;141(2):207-213. https://doi.org/10.1016/s0166-4328(02)00369-8.
Janickova H, Kljakic O, Rosborough K, et al. Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition but markedly increases susceptibility to stress. FASEB J. 2019;33(6):7018-7036. https://doi.org/10.1096/fj.201802108R.
Morton AJ, Skillings E, Bussey TJ, Saksida LM. Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system. Nat Methods. 2006;3(10):767. https://doi.org/10.1038/nmeth1006-767.
Bussey TJ, Padain TL, Skillings EA, Winters BD, Morton AJ, Saksida LM. The touchscreen cognitive testing method for rodents: how to get the best out of your rat. Learn Mem. 2008;15(7):516-523. https://doi.org/10.1101/lm.987808.
Graybeal C, Bachu M, Mozhui K, et al. Strains and stressors: an analysis of touchscreen learning in genetically diverse mouse strains. PLoS One. 2014;9(2):e87745. https://doi.org/10.1371/journal.pone.0087745.
Phillips BU, Heath CJ, Ossowska Z, Bussey TJ, Saksida LM. Optimisation of cognitive performance in rodent operant (touchscreen) testing: evaluation and effects of reinforcer strength. Learn Behav. 2017;45(3):252-262. https://doi.org/10.3758/s13420-017-0260-7.
Kim EW, Phillips BU, Heath CJ, et al. Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens. Mol Brain. 2017;10(1):31. https://doi.org/10.1186/s13041-017-0312-0.
Shansky RM, Woolley CS. Considering sex as a biological variable will be valuable for neuroscience research. J Neurosci. 2016;36(47):11817-11822. https://doi.org/10.1523/JNEUROSCI.1390-16.2016.
Shansky RM. Are hormones a "female problem" for animal research? Science. 2019;364(6443):825-826. https://doi.org/10.1126/science.aaw7570.
Markham MR, Butt AE, Dougher MJ. A computer touch-screen apparatus for training visual discriminations in rats. J Exp Anal Behav. 1996;65(1):173-182. https://doi.org/10.1901/jeab.1996.65-173.
Aggleton JP, Keen S, Warburton EC, Bussey TJ. Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Res Bull. 1997;43(3):279-287. https://doi.org/10.1016/s0361-9230(97)00007-5.
Brigman JL, Bussey TJ, Saksida LM, Rothblat LA. Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts. Behav Neurosci. 2005;119(3):839-842. https://doi.org/10.1037/0735-7044.119.3.839.
Talpos JC, Winters BD, Dias R, Saksida LM, Bussey TJ. A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. Psychopharmacology (Berl). 2009;205(1):157-168. https://doi.org/10.1007/s00213-009-1526-3.
Talpos JC, Aerts N, Fellini L, Steckler T. A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment. Pharmacol Biochem Behav. 2014;122:97-106. https://doi.org/10.1016/j.pbb.2014.03.014.
Clelland CD, Choi M, Romberg C, et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science. 2009;325(5937):210-213. https://doi.org/10.1126/science.1173215.
Bartko SJ, Vendrell I, Saksida LM, Bussey TJ. A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil. Psychopharmacology (Berl). 2011;214(2):537-548. https://doi.org/10.1007/s00213-010-2050-1.
Nithianantharajah J, Komiyama NH, McKechanie A, et al. Synaptic scaffold evolution generated components of vertebrate cognitive complexity. Nat Neurosci. 2013;16(1):16-24. https://doi.org/10.1038/nn.3276.
Delotterie D, Mathis C, Cassel JC, Dorner-Ciossek C, Marti A. Optimization of touchscreen-based behavioral paradigms in mice: implications for building a battery of tasks taxing learning and memory functions. PLoS One. 2014;9(6):e100817. https://doi.org/10.1371/journal.pone.0100817.
Kim J, Wasserman EA, Castro L, Freeman JH. Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory. Behav Neurosci. 2016;130(1):75-90. https://doi.org/10.1037/bne0000117.
Whoolery CW, Yun S, Reynolds RP, et al. Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation. Sci Rep. 2020;10(1):2737. https://doi.org/10.1038/s41598-020-59419-z.
Talpos JC, McTighe SM, Dias R, Saksida LM, Bussey TJ. Trial-unique, delayed nonmatching-to-location (TUNL): a novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation. Neurobiol Learn Mem. 2010;94(3):341-352. https://doi.org/10.1016/j.nlm.2010.07.006.
McAllister KA, Saksida LM, Bussey TJ. Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL task. Neurobiol Learn Mem. 2013;101:120-126. https://doi.org/10.1016/j.nlm.2013.01.010.
Hvoslef-Eide M, Oomen CA, Fisher BM, et al. Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine. Psychopharmacology (Berl). 2015;232(21-22):4005-4016. https://doi.org/10.1007/s00213-015-4038-3.
Oomen CA, Hvoslef-Eide M, Kofink D, et al. A novel 2- and 3-choice touchscreen-based continuous trial-unique nonmatching-to-location task (cTUNL) sensitive to functional differences between dentate gyrus and CA3 subregions of the hippocampus. Psychopharmacology (Berl). 2015;232(21-22):3921-3933. https://doi.org/10.1007/s00213-015-4019-6.
Kenton JA, Castillo R, Holmes A, Brigman JL. Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm. Neurobiol Learn Mem. 2018;156:60-67. https://doi.org/10.1016/j.nlm.2018.10.011.
Kim CH, Romberg C, Hvoslef-Eide M, et al. Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction. Psychopharmacology (Berl). 2015;232(21-22):3935-3945. https://doi.org/10.1007/s00213-015-4017-8.
Kwak C, Lim CS, Kaang BK. Development of a touch-screen-based paradigm for assessing working memory in the mouse. Exp Neurobiol. 2015;24(1):84-89. https://doi.org/10.5607/en.2015.24.1.84.
McTighe SM, Mar AC, Romberg C, Bussey TJ, Saksida LM. A new touchscreen test of pattern separation: effect of hippocampal lesions. Neuroreport. 2009;20(9):881-885. https://doi.org/10.1097/WNR.0b013e32832c5eb2.
Chemla S, Muller L, Reynaud A, Takerkart S, Destexhe A, Chavane F. Improving voltage-sensitive dye imaging: with a little help from computational approaches. Neurophotonics. 2017;4(3):031215. https://doi.org/10.1117/1.NPh.4.3.031215.
Creer DJ, Romberg C, Saksida LM, Praag H, Bussey TJ. Running enhances spatial pattern separation in mice. Proc Natl Acad Sci U S A. 2010;107(5):2367-2372. https://doi.org/10.1073/pnas.0911725107.
Coba MP, Komiyama NH, Nithianantharajah J, et al. TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci. 2012;32(40):13987-13999. https://doi.org/10.1523/JNEUROSCI.2433-12.2012.
Zhuo JM, Tseng HA, Desai M, et al. Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks. Elife. 2016;5:e22429. https://doi.org/10.7554/eLife.22429.
Braida D, Donzelli A, Martucci R, et al. Mice discriminate between stationary and moving 2D shapes: application to the object recognition task to increase attention. Behav Brain Res. 2013;242:95-101. https://doi.org/10.1016/j.bbr.2012.12.040.
Romberg C, McTighe SM, Heath CJ, et al. False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine. Brain. 2012;135(Pt 7):2103-2114. https://doi.org/10.1093/brain/aws074.
Reichelt AC, Palmer D, Shaikh S, Bussey TJ, Saksida LM. Optimization of a touchscreen spontaneous object recognition task for optogenetics in mice. The Canadian Association for Neuroscience 2019 Scientific Program. Toronto, Ontario, Canada: The Canadian Association for Neuroscience; 2019.
Bussey TJ, Duck J, Muir JL, Aggleton JP. Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat. Behav Brain Res. 2000;111(1-2):187-202. https://doi.org/10.1016/s0166-4328(00)00155-8.
Chudasama Y, Bussey TJ, Muir JL. Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning. Eur J Neurosci. 2001;14(6):1009-1020. https://doi.org/10.1046/j.0953-816x.2001.01607.x.
Janisiewicz AM, Baxter MG. Transfer effects and conditional learning in rats with selective lesions of medial septal/diagonal band cholinergic neurons. Behav Neurosci. 2003;117(6):1342-1352. https://doi.org/10.1037/0735-7044.117.6.1342.
Princz-Lebel O, Wasserman D, Skirzewski M, MacDonald P, Bussey T, Saksida L. Optimization of the touchscreen-based visuomotor conditional learning task in mice. The Canadian Association for Neuroscience (CAN-ACN) 2019 Scientific Program. Toronto, Ontario, Canada: The Canadian Association for Neuroscience; 2019.
Talpos JC, Dias R, Bussey TJ, Saksida LM. Hippocampal lesions in rats impair learning and memory for locations on a touch-sensitive computer screen: the "ASAT" task. Behav Brain Res. 2008;192(2):216-225. https://doi.org/10.1016/j.bbr.2008.04.008.
Kumar G, Talpos J, Steckler T. Strain-dependent effects on acquisition and reversal of visual and spatial tasks in a rat touchscreen battery of cognition. Physiol Behav. 2015;144:26-36. https://doi.org/10.1016/j.physbeh.2015.03.001.
Buscher N, van Dorsselaer P, Steckler T, Talpos JC. Evaluating aged mice in three touchscreen tests that differ in visual demands: impaired cognitive function and impaired visual abilities. Behav Brain Res. 2017;333:142-149. https://doi.org/10.1016/j.bbr.2017.06.053.
Kljakic O, Janickova H, Skirzewski Prieto M, et al. Motivation and Cue-Directed Effort Are Regulated by Acetylcholine/Glutamate Co-Transmission from Striatal Cholinergic Interneurons. London, Ontario, Canada: International Touchscreen Symposium: Virtual Edition; 2020.
Bussey TJ, Clea Warburton E, Aggleton JP, Muir JL. Fornix lesions can facilitate acquisition of the transverse patterning task: a challenge for "configural" theories of hippocampal function. J Neurosci. 1998;18(4):1622-1631. https://doi.org/10.1523/JNEUROSCI.18-04-01622.1998.
Broschard MB, Kim J, Love BC, Freeman JH. Category learning in rodents using touchscreen-based tasks. Genes Brain Behav. 2021;20:e12665. https://doi.org/10.1111/gbb.12665.
Silverman JL, Gastrell PT, Karras MN, Solomon M, Crawley JN. Cognitive abilities on transitive inference using a novel touchscreen technology for mice. Cereb Cortex. 2015;25(5):1133-1142. https://doi.org/10.1093/cercor/bht293.
Norris RHC, Churilov L, Hannan AJ, Nithianantharajah J. Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference. Mol Autism. 2019;10:42. https://doi.org/10.1186/s13229-019-0292-2.
Steckler T, Sahgal A. Psychopharmacological studies in rats responding at touch-sensitive devices. Psychopharmacology (Berl). 1995;118(2):226-229. https://doi.org/10.1007/BF02245846.
Christakou A, Robbins TW, Everitt BJ. Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function. Behav Neurosci. 2001;115(4):812-825. https://doi.org/10.1037//0735-7044.115.4.812.
Romberg C, Mattson MP, Mughal MR, Bussey TJ, Saksida LM. Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). J Neurosci. 2011;31(9):3500-3507. https://doi.org/10.1523/JNEUROSCI.5242-10.2011.
Kolisnyk B, Al-Onaizi MA, Hirata PH, et al. Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex. J Neurosci. 2013;33(37):14908-14920. https://doi.org/10.1523/JNEUROSCI.1933-13.2013.
Mar AC, Nilsson SRO, Gamallo-Lana B, et al. MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl). 2017;234(19):2837-2857. https://doi.org/10.1007/s00213-017-4679-5.
Ding Z, Brown JW, Rueter LE, Mohler EG. Profiling attention and cognition enhancing drugs in a rat touchscreen-based continuous performance test. Psychopharmacology (Berl). 2018;235(4):1093-1105. https://doi.org/10.1007/s00213-017-4827-y.
Kim CH, Hvoslef-Eide M, Nilsson SR, et al. The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function. Psychopharmacology (Berl). 2015;232(21-22):3947-3966. https://doi.org/10.1007/s00213-015-4081-0.
Hvoslef-Eide M, Nilsson SR, Hailwood JM, et al. Effects of anterior cingulate cortex lesions on a continuous performance task for mice. Brain Neurosci Adv. 2018;2398212818772962:2. https://doi.org/10.1177/2398212818772962.
Braeckman K, Descamps B, Vanhove C, Caeyenberghs K. Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury: a diffusion MRI study. Brain Imaging Behav. 2019. https://doi.org/10.1007/s11682-019-00179-4.
Wicks B, Waxler DE, White KM, et al. Method for testing sustained attention in touchscreen operant chambers in rats. J Neurosci Methods. 2017;277:30-37. https://doi.org/10.1016/j.jneumeth.2016.12.003.
Bangasser DA, Wicks B, Waxler DE, Eck SR. Touchscreen sustained attention task (SAT) for rats. J Vis Exp. 2017;(127):56219. https://doi.org/10.3791/56219.
You WK, Mysore SP. Endogenous and exogenous control of visuospatial selective attention in freely behaving mice. Nat Commun. 2020;11(1):1986. https://doi.org/10.1038/s41467-020-15909-2.
Li S, May C, Hannan, AJ, et al. Assessing Attention Orienting in Mice: a novel touchscreen adaptation of the posner-style cueing task. https://www.biorxiv.org/content/biorxiv/early/2020/06/06/2020.06.05.136689.full.pdf
Cho BR, Kwak MJ, Kim WY, Kim JH. Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Front Psych. 2018;9:503. https://doi.org/10.3389/fpsyt.2018.00503.
Humby T, Smith GE, Small R, et al. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology (Berl). 2020;237(6):1745-1756. https://doi.org/10.1007/s00213-020-05496-x.
Palmer, D. Role of medial and lateral orbitofrontal cortex in gambling-based decision making.
Glover LR, Postle AF, Holmes A. Touchscreen-based assessment of risky-choice in mice. Behav Brain Res. 2020;112748393 https://doi.org/10.1016/j.bbr.2020.112748.
Abela AR, Chudasama Y. Dissociable contributions of the ventral hippocampus and orbitofrontal cortex to decision-making with a delayed or uncertain outcome. Eur J Neurosci. 2013;37(4):640-647. https://doi.org/10.1111/ejn.12071.
Abela AR, Chudasama Y. Noradrenergic α2A-receptor stimulation in the ventral hippocampus reduces impulsive decision-making. Psychopharmacology (Berl). 2014;231(3):521-531. https://doi.org/10.1007/s00213-013-3262-y.
Phillips B. Touchscreen Assessment of Motivation and Reinforcement-Related Choice Behaviour in Mice. Doctoral Dissertation. University of Cambridge: Cambridge, UK; 2018.
Heath CJ, Bussey TJ, Saksida LM. Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs. Psychopharmacology (Berl). 2015;232(21-22):4043-4057. https://doi.org/10.1007/s00213-015-4009-8.
Yang JH, Presby RE, Jarvie AA, et al. Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction. Psychopharmacology (Berl). 2020;237(1):33-43. https://doi.org/10.1007/s00213-019-05343-8.
Lopez-Cruz L, Phillips Bu, Hailwood JM. (2017) Development and optimization of a touchscreen-based effort discounting task for evaluation of motivation in mice: effect of dopaminergic drugs.
Bussey TJ, Muir JL, Everitt BJ, Robbins TW. Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat. Behav Neurosci. 1997;111(5):920-936. https://doi.org/10.1037//0735-7044.111.5.920.
Chudasama Y, Robbins TW. Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex. J Neurosci. 2003;23(25):8771-8780. https://doi.org/10.1523/JNEUROSCI.23-25-08771.2003.
Brigman JL, Padukiewicz KE, Sutherland ML, Rothblat LA. Executive functions in the heterozygous reeler mouse model of schizophrenia. Behav Neurosci. 2006;120(4):984-988. https://doi.org/10.1037/0735-7044.120.4.984.
Izquierdo A, Wiedholz LM, Millstein RA, et al. Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice. Behav Brain Res. 2006;171(2):181-188. https://doi.org/10.1016/j.bbr.2006.03.029.
Piantadosi PT, Lieberman AG, Pickens CL, Bergstrom HC, Holmes A. A novel multichoice touchscreen paradigm for assessing cognitive flexibility in mice. Learn Mem. 2018;26(1):24-30. https://doi.org/10.1101/lm.048264.118.
Reynaud A, Takerkart S, Masson GS, Chavane F. Linear model decomposition for voltage-sensitive dye imaging signals: application in awake behaving monkey. Neuroimage. 2011;54(2):1196-1210. https://doi.org/10.1016/j.neuroimage.2010.08.041.
Dickson PE, Calton MA, Mittleman G. Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task. Behav Brain Res. 2014;261:158-170. https://doi.org/10.1016/j.bbr.2013.12.015.
Dickson PE, Cairns J, Goldowitz D, Mittleman G. Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice. Neuroscience. 2017;345:99-109. https://doi.org/10.1016/j.neuroscience.2016.03.040.
McAllister KAL. Development and Validation of Touchscreen Automated Tasks to Assess Cognition in Preclinical Models of Schizophrenia. Cambridge UK: Doctoral Dissertation, University of Cambridge; 2012.
Dalley JW, Chudasama Y, Theobald DE, Pettifer CL, Fletcher CM, Robbins TW. Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration. Psychopharmacology (Berl). 2002;161(4):425-433. https://doi.org/10.1007/s00213-002-1078-2.
Brigman JL, Feyder M, Saksida LM, Bussey TJ, Mishina M, Holmes A. Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. Learn Mem. 2008;15(2):50-54. https://doi.org/10.1101/lm.777308.
Hefner K, Whittle N, Juhasz J, et al. Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain. J Neurosci. 2008;28(32):8074-8085. https://doi.org/10.1523/JNEUROSCI.4904-07.2008.
Lederle L, Weber S, Wright T, et al. Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains. PLoS One. 2011;6(1):e15536. https://doi.org/10.1371/journal.pone.0015536.
Ahn JR, Lee I. Intact CA3 in the hippocampus is only sufficient for contextual behavior based on well-learned and unaltered visual background. Hippocampus. 2014;24(9):1081-1093. https://doi.org/10.1002/hipo.22292.
Rutz HL, Rothblat LA. Intact and impaired executive abilities in the BTBR mouse model of autism. Behav Brain Res. 2012;234(1):33-37. https://doi.org/10.1016/j.bbr.2012.05.048.
Richter SH, Vogel AS, Ueltzhöffer K, et al. Touchscreen-paradigm for mice reveals cross-species evidence for an antagonistic relationship of cognitive flexibility and stability. Front Behav Neurosci. 2014;8:154. https://doi.org/10.3389/fnbeh.2014.00154.
Hailwood JM, Heath CJ, Robbins TW, Saksida LM, Bussey TJ. Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats. Psychopharmacology (Berl). 2018;235(9):2739-2753. https://doi.org/10.1007/s00213-018-4969-6.
Wilkinson MP, Grogan JP, Mellor JR, Robinson ESJ. Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task. Brain Neurosci Adv. 2020;4:2398212820907177. https://doi.org/10.1177/2398212820907177.
Phillips BU, Dewan S, Nilsson SRO, et al. Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology (Berl). 2018;235(7):2101-2111. https://doi.org/10.1007/s00213-018-4907-7.
Inglis WL, Olmstead MC, Robbins TW. Pedunculopontine tegmental nucleus lesions impair stimulus-reward learning in autoshaping and conditioned reinforcement paradigms. Behav Neurosci. 2000;114(2):285-294. https://doi.org/10.1037//0735-7044.114.2.285.
Parkinson JA, Willoughby PJ, Robbins TW, Everitt BJ. Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: further evidence for limbic cortical-ventral striatopallidal systems. Behav Neurosci. 2000;114(1):42-63.
Dalley JW, Lääne K, Theobald DE, et al. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc Natl Acad Sci U S A. 2005;102(17):6189-6194. https://doi.org/10.1073/pnas.0502080102.
Mosser C-A, Haqqee Z, Nieto-Posadas A, Murai K, Stifani S, Williams S, Brandon MP. The McGill-Mouse-Miniscope platform: A standardized approach for high-throughput imaging of neuronal dynamics during behavior. Genes, Brain and Behavior. 2021;20:e12686. https://doi.org/10.1111/gbb.12686.
Krakenberg V, von Kortzfleisch VT, Kaiser S, Sachser N, Richter SH. Differential effects of serotonin transporter genotype on anxiety-like behavior and cognitive judgment Bias in mice. Front Behav Neurosci. 2019;13:263. https://doi.org/10.3389/fnbeh.2019.00263.
Romberg C, Horner AE, Bussey TJ, Saksida LM. A touch screen-automated cognitive test battery reveals impaired attention, memory abnormalities, and increased response inhibition in the TgCRND8 mouse model of Alzheimer's disease. Neurobiol Aging. 2013;34(3):731-744. https://doi.org/10.1016/j.neurobiolaging.2012.08.006.
Hvoslef-Eide M, Mar AC, Nilsson SR, et al. The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology (Berl). 2015;232(21-22):3853-3872. https://doi.org/10.1007/s00213-015-4007-x.
Nithianantharajah J, McKechanie AG, Stewart TJ, et al. Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. Sci Rep. 2015;5:14613. https://doi.org/10.1038/srep14613.
Romberg C, Bussey TJ, Saksida LM. Paying more attention to attention: towards more comprehensive cognitive translation using mouse models of Alzheimer's disease. Brain Res Bull. 2013;92:49-55. https://doi.org/10.1016/j.brainresbull.2012.02.007.
Sahakian BJ, Coull JT. Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB. Acta Neurol Scand Suppl. 1993;149:29-35. https://doi.org/10.1111/j.1600-0404.1993.tb04251.x.
Heath CJ, O'Callaghan C, Mason SL, et al. A touchscreen motivation assessment evaluated in Huntington's disease patients and R6/1 model mice. Front Neurol. 2019;10:858. https://doi.org/10.3389/fneur.2019.00858.
Horner AE, Heath CJ, Hvoslef-Eide M, et al. The touchscreen operant platform for testing learning and memory in rats and mice. Nat Protoc. 2013;8(10):1961-1984. https://doi.org/10.1038/nprot.2013.122.
Mar AC, Horner AE, Nilsson SR, et al. The touchscreen operant platform for assessing executive function in rats and mice. Nat Protoc. 2013;8(10):1985-2005. https://doi.org/10.1038/nprot.2013.123.
Oomen CA, Hvoslef-Eide M, Heath CJ, et al. The touchscreen operant platform for testing working memory and pattern separation in rats and mice. Nat Protoc. 2013;8(10):2006-2021. https://doi.org/10.1038/nprot.2013.124.
Heath C, Phillips B, Bussey T, Saksida L. Measuring motivation and reward-related decision making in the rodent operant touchscreen system. Curr Protoc Neurosci. 2016;74(8.34):1-8.
Dumont JR, Salewski R, Beraldo F. Critical mass: the rise of a touchscreen technology community for rodent cognitive testing. Genes Brain Behav. 2021;20:e12650. https://doi.org/10.1111/gbb.12650.
Luo L, Ambrozkiewicz MC, Benseler F, et al. Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of Germline recombination and influencing factors. Neuron. 2020;106(1):37-65.e5. https://doi.org/10.1016/j.neuron.2020.01.008.
Madisen L, Garner AR, Shimaoka D, et al. Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance. Neuron. 2015;85(5):942-958. https://doi.org/10.1016/j.neuron.2015.02.022.
Chan KY, Jang MJ, Yoo BB, et al. Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nat Neurosci. 2017;20(8):1172-1179. https://doi.org/10.1038/nn.4593.
Deverman BE, Pravdo PL, Simpson BP, et al. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol. 2016;34(2):204-209. https://doi.org/10.1038/nbt.3440.
Deisseroth K. Optogenetics. Nat Methods. 2011;8(1):26-29. https://doi.org/10.1038/nmeth.f.324.
Roth BL. DREADDs for neuroscientists. Neuron. 2016;89(4):683-694. https://doi.org/10.1016/j.neuron.2016.01.040.
Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005;8(9):1263-1268. https://doi.org/10.1038/nn1525.
Deisseroth K. Optogenetics: 10 years of microbial opsins in neuroscience. Nat Neurosci. 2015;18(9):1213-1225. https://doi.org/10.1038/nn.4091.
Gunaydin LA, Grosenick L, Finkelstein JC, et al. Natural neural projection dynamics underlying social behavior. Cell. 2014;157(7):1535-1551. https://doi.org/10.1016/j.cell.2014.05.017.
Ghosh KK, Burns LD, Cocker ED, et al. Miniaturized integration of a fluorescence microscope. Nat Methods. 2011;8(10):871-878. https://doi.org/10.1038/nmeth.1694.
Gradinaru V, Zhang F, Ramakrishnan C, et al. Molecular and cellular approaches for diversifying and extending optogenetics. Cell. 2010;141(1):154-165. https://doi.org/10.1016/j.cell.2010.02.037.
Chuong AS, Miri ML, Busskamp V, et al. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014;17(8):1123-1129. https://doi.org/10.1038/nn.3752.
Deisseroth K, Hegemann P. The form and function of channelrhodopsin. Science. 2017;357(6356):5544. https://doi.org/10.1126/science.aan5544.
Stein RB, Gossen ER, Jones KE. Neuronal variability: noise or part of the signal? Nat Rev Neurosci. 2005;6(5):389-397. https://doi.org/10.1038/nrn1668.
Jing M, Zhang Y, Wang H, Li Y. G-protein-coupled receptor-based sensors for imaging neurochemicals with high sensitivity and specificity. J Neurochem. 2019;151(3):279-288. https://doi.org/10.1111/jnc.14855.
Chen TW, Wardill TJ, Sun Y, et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature. 2013;499(7458):295-300. https://doi.org/10.1038/nature12354.
Piatkevich KD, Bensussen S, Tseng HA, et al. Population imaging of neural activity in awake behaving mice. Nature. 2019;574(7778):413-417. https://doi.org/10.1038/s41586-019-1641-1.
Sadakane O, Masamizu Y, Watakabe A, et al. Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human Primates. Cell Rep. 2015;13(9):1989-1999. https://doi.org/10.1016/j.celrep.2015.10.050.
Marvin JS, Borghuis BG, Tian L, et al. An optimized fluorescent probe for visualizing glutamate neurotransmission. Nat Methods. 2013;10(2):162-170. https://doi.org/10.1038/nmeth.2333.
Jing M, Zhang P, Wang G, et al. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nat Biotechnol. 2018;36(8):726-737. https://doi.org/10.1038/nbt.4184.
Patriarchi T, Cho JR, Merten K, et al. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science. 2018;360(6396):4422. https://doi.org/10.1126/science.aat4422.
Sun F, Zeng J, Jing M, et al. A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell. 2018;174(2):481-496.e19. https://doi.org/10.1016/j.cell.2018.06.042.
Feng J, Zhang C, Lischinsky JE, et al. A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron. 2019;102(4):745-761.e8. https://doi.org/10.1016/j.neuron.2019.02.037.
Ferreira-Vieira TH, Guimaraes IM, Silva FR, Ribeiro FM. Alzheimer's disease: targeting the cholinergic system. Curr Neuropharmacol. 2016;14(1):101-115. https://doi.org/10.2174/1570159x13666150716165726.
Cowen PJ, Browning M. What has serotonin to do with depression? World Psychiatry. 2015;14(2):158-160. https://doi.org/10.1002/wps.20229.
Tye KM. Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease? Neuron. 2014;83(6):1259-1261. https://doi.org/10.1016/j.neuron.2014.08.022.
Calhoon GG, Tye KM. Resolving the neural circuits of anxiety. Nat Neurosci. 2015;18(10):1394-1404. https://doi.org/10.1038/nn.4101.
Werner CT, Williams CJ, Fermelia MR, Lin DT, Li Y. Circuit mechanisms of neurodegenerative diseases: a new frontier with miniature fluorescence microscopy. Front Neurosci. 2019;13:1174. https://doi.org/10.3389/fnins.2019.01174.
Chemla S, Chavane F. Voltage-sensitive dye imaging: technique review and models. J Physiol Paris. 2010;104(1-2):40-50. https://doi.org/10.1016/j.jphysparis.2009.11.009.
Alexander DM, Jurica P, Trengove C, et al. Traveling waves and trial averaging: the nature of single-trial and averaged brain responses in large-scale cortical signals. Neuroimage. 2013;73:95-112. https://doi.org/10.1016/j.neuroimage.2013.01.016.
Muller L, Reynaud A, Chavane F, Destexhe A. The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave. Nat Commun. 2014;5:3675. https://doi.org/10.1038/ncomms4675.
Beraldo FH, Palmer D, Memar S, et al. MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. Elife. 2019;8:e49630. https://doi.org/10.7554/eLife.49630.