Zero-valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering.
Animals
Astrocytes
/ cytology
Cell Adhesion
Cell Death
Electric Conductivity
Ganglia, Spinal
/ metabolism
Humans
Iron
/ chemistry
Metal Nanoparticles
/ chemistry
Mice
Mice, Inbred BALB C
NIH 3T3 Cells
Nanofibers
/ chemistry
Nerve Tissue
/ physiology
Polyesters
/ chemistry
Tensile Strength
Tissue Engineering
Tissue Scaffolds
/ chemistry
electrospin
iron nanoparticles
nerve regeneration
polycaprolactone
tissue engineering
zero valent
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
05
05
2020
revised:
25
08
2020
accepted:
10
09
2020
pubmed:
4
10
2020
medline:
15
10
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
Regeneration of nerve tissue is a challenging issue in regenerative medicine. Especially, the peripheral nerve defects related to the accidents are one of the leading health problems. For large degeneration of peripheral nerve, nerve grafts are used in order to obtain a connection. These grafts should be biodegradable to prevent second surgical intervention. In order to make more effective nerve tissue engineering materials, nanotechnological improvements were used. Especially, the addition of electrically conductive and biocompatible metallic particles and carbon structures has essential roles in the stimulation of nerves. However, the metabolizing of these structures remains to wonder because of their nondegradable nature. In this study, biodegradable and conductive nerve tissue engineering materials containing zero-valent iron (Fe) nanoparticles were developed and investigated under in vitro conditions. By using electrospinning technique, fibrous mats composed of electrospun poly(ε-caprolactone) (PCL) nanofibers and Fe nanoparticles were obtained. Both electrical conductivity and mechanical properties increased compared with control group that does not contain nanoparticles. Conductivity of PCL/Fe5 and PCL/Fe10 increased to 0.0041 and 0.0152 from 0.0013 Scm
Substances chimiques
Polyesters
0
polycaprolactone
24980-41-4
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1815-1826Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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