Short communication: Efficacy of albendazole in Echinococcus multilocularis-infected mice depends on the functional immunity of the host.

Albendazole / pharmacology Animals Anticestodal Agents / pharmacology Disease Models, Animal Echinococcosis, Hepatic / drug therapy Echinococcus multilocularis / drug effects Immunocompromised Host Mice Mice, Nude Random Allocation
Alveolar echinococcosis Benzimidazole Immunity Immunomodulation Treatment

Journal

Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 08 07 2020
revised: 08 09 2020
accepted: 29 09 2020
pubmed: 4 10 2020
medline: 15 12 2020
entrez: 3 10 2020
Statut: ppublish

Résumé

Alveolar echinococcosis (AE) is a deadly parasitic disease that requires lifelong treatment with albendazole. Development of host immunity is pivotal with regard to the clinical outcome of AE, but its influence on conventional albendazole treatment is unknown. Using T-cell deficient athymic nude mice, we demonstrated that functional immunity is required for albendazole to be efficacious against murine AE. These results call for attention given the increasing number of immunocompromised patients with AE.

Identifiants

DOI: 10.1016/j.exppara.2020.108013 PMID: 33010287
pubmed: 33010287
pii: S0014-4894(20)30363-5
doi: 10.1016/j.exppara.2020.108013
pii:
doi:

Substances chimiques

Anticestodal Agents 0
Albendazole F4216019LN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108013

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Junhua Wang (J)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland; Institute for Infectious Diseases, Faculty of Medicine, University of Berne, Friedbühlstrasse 51, 3010, Berne, Switzerland.

Nelson Marreros (N)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland.

Reto Rufener (R)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland.

Andrew Hemphill (A)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland.

Bruno Gottstein (B)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland; Institute for Infectious Diseases, Faculty of Medicine, University of Berne, Friedbühlstrasse 51, 3010, Berne, Switzerland.

Britta Lundström-Stadelmann (B)

Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Berne, Längassstrasse 122, 3012, Berne, Switzerland. Electronic address: britta.lundstroem@vetsuisse.unibe.ch.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Albendazole › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Eucaryotes › Animaux › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Antihelminthiques antiplathelminthes › Antihelminthiques anticestodes › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Parasitoses hépatiques › Échinococcose hépatique › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Cestoda › Echinococcus › Echinococcus multilocularis › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Phénomènes du système immunitaire › Sujet immunodéprimé › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Short communication: Efficacy of albendazole...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Short communication: Efficacy of albendazole...