Profound tabletability deterioration of microcrystalline cellulose by magnesium stearate.
Lubrication
Magnesium stearate
Microcrystalline cellulose
Mixing intensity
Tabletability
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Nov 2020
30 Nov 2020
Historique:
received:
25
06
2020
revised:
20
09
2020
accepted:
25
09
2020
pubmed:
4
10
2020
medline:
22
6
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
Magnesium stearate (MgSt) is a common lubricant used in tablet formulations to facilitate tablet manufacturing by reducing ejection force. The use of MgSt in tablet formulation is known to potentially deteriorate tabletability of plastic powders and slow down drug dissolution. Here, we report surprisingly profound deterioration in tabletability of microcrystalline cellulose by hand-mixing. We also show that the hand mixing process is highly variable. To ensure the reproducibility of tabletability assessment of powders, hand-mixing should be used with caution. For research that employs hand mixing, mixing procedure should be carefully controlled and reported.
Identifiants
pubmed: 33010396
pii: S0378-5173(20)30912-1
doi: 10.1016/j.ijpharm.2020.119927
pii:
doi:
Substances chimiques
Powders
0
Stearic Acids
0
Tablets
0
stearic acid
4ELV7Z65AP
Cellulose
9004-34-6
microcrystalline cellulose
OP1R32D61U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119927Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.