Sex differences in brain metabolites in anxiety and mood disorders.
Generalized anxiety disorder
Magnetic resonance spectroscopy
Major depressive disorder
Panic disorder
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 11 2020
30 11 2020
Historique:
received:
31
03
2020
revised:
15
09
2020
accepted:
17
09
2020
pubmed:
4
10
2020
medline:
1
3
2022
entrez:
3
10
2020
Statut:
ppublish
Résumé
Gender differences in mood and anxiety disorders are well-established. However, the neural basis of these differences is not clear yet, especially in terms of brain metabolism. Indeed, although several proton Magnetic Resonance Spectroscopy (¹H MRS) investigations reported different metabolic levels in both depression and anxiety disorders, which have been also linked to symptoms severity and response to treatment, the role of gender on these differences have not been explored yet. Therefore, this study aims at investigating the role of sex in neurometabolic alterations associated with both mood and anxiety disorders. A 3T single-voxel ¹H MRS acquisition of the dorsolateral prefrontal cortex was acquired from 14 Major Depressive Disorder, 10 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD), patients and 16 healthy controls (HC). Among males, PD patients showed significantly lower GPC+PC (also observed in GAD+PD) and Glu levels compared to HC. Finally, a significant group x sex interaction effect was observed in the GPC+PC and Glu levels. We proved the presence of an association between sex and brain metabolites in anxiety spectrum.
Identifiants
pubmed: 33010582
pii: S0925-4927(20)30168-2
doi: 10.1016/j.pscychresns.2020.111196
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111196Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.