Validation of plasma metabolites associated with breast cancer risk among Mexican Americans.
Breast cancer
Metabolomics
Mexican americans
Journal
Cancer epidemiology
ISSN: 1877-783X
Titre abrégé: Cancer Epidemiol
Pays: Netherlands
ID NLM: 101508793
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
06
05
2020
revised:
26
08
2020
accepted:
14
09
2020
pubmed:
4
10
2020
medline:
13
4
2021
entrez:
3
10
2020
Statut:
ppublish
Résumé
In our previous breast cancer case control study in Hispanics, we found 14 metabolites whose levels differed between cases and controls. To validate the results, we carried out a nested case control study of 100 incident breast cancer and 100 matched healthy women identified from the Mano-A-Mano Mexican American Cohort study. With the adjustment of parity, education, birth place, language acculturation, BMI category, smoking, drinking, physical activity, and sitting time, 4 metabolites were associated with breast cancer risk: 3-hydroxyoctanoate (Odds ratio (OR) = 1.51, 95% confidence interval (CI): 1.10, 3.47), 3-hydroxybutyrate (BHBA) (OR = 1.42, 95%CI: 1.01, 3.72), linoleate (18:2n6) (OR = 1.39, 95% CI: 1.07, 4.04), and bilirubin (OR = 0.54, 95%CI: 0.42, 0.95). Then, we used 3 non-redundant metabolites, namely 3-hydroxyoctanoate, linoleate (18:2n6), and bilirubin, to generate a metabolic risk score. Increased metabolites risk score was associated with a 1.67-fold increased risk of breast cancer (OR = 1.67, 95%CI: 1.32, 3.94). And the significant association was more evident among those who were diagnosed with cancer earlier during the follow-up (≤ 5 years) than their counterparts. In conclusion, we identified four significant metabolites which may help elucidate metabolic pathways that contribute to breast carcinogenesis. Our findings warrant further replication efforts.
Identifiants
pubmed: 33010726
pii: S1877-7821(20)30160-0
doi: 10.1016/j.canep.2020.101826
pmc: PMC7710579
mid: NIHMS1631132
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101826Subventions
Organisme : NCI NIH HHS
ID : U01 CA179655
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Breast Cancer Res Treat. 2011 Apr;126(3):717-27
pubmed: 20872241
Cancer Causes Control. 2001 Dec;12(10):887-94
pubmed: 11808707
Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):631-40
pubmed: 23396963
Biochim Biophys Acta. 2013 Oct;1831(10):1533-41
pubmed: 23500888
Metabolomics. 2018 Jul 6;14(7):97
pubmed: 30830410
CA Cancer J Clin. 2018 Nov;68(6):425-445
pubmed: 30285281
Crit Rev Oncol Hematol. 2012 Oct;84(1):1-7
pubmed: 22429650
J Cell Physiol. 2016 Oct;231(10):2128-41
pubmed: 26844415
Clin Cancer Res. 2015 Jan 1;21(1):193-200
pubmed: 25336700
Breast Cancer Res Treat. 2019 Aug;176(3):687-696
pubmed: 30771047
Am J Clin Nutr. 2017 Aug;106(2):637-649
pubmed: 28659298
Biomed Chromatogr. 2016 Jan;30(1):42-7
pubmed: 26179699
Br J Cancer. 2017 Nov 7;117(10):1572-1579
pubmed: 28898231
JAMA. 2011 Feb 16;305(7):691-7
pubmed: 21325185
Int J Mol Med. 2012 Sep;30(3):487-94
pubmed: 22692672
Cancer Res. 2018 Oct 15;78(20):6011-6021
pubmed: 30185547
CA Cancer J Clin. 2018 Jan;68(1):31-54
pubmed: 29160902
J Natl Cancer Inst. 2018 Jun 1;110(6):588-597
pubmed: 29325144
Int J Epidemiol. 2017 Apr 1;46(2):e3
pubmed: 25747868
PLoS One. 2013 May 02;8(5):e63076
pubmed: 23658799
Cell Metab. 2018 Jan 9;27(1):136-150.e5
pubmed: 29249690
Carcinogenesis. 2015 Feb;36(2):243-8
pubmed: 25524924
Nutrients. 2018 May 22;10(5):
pubmed: 29789452
Int J Biochem Cell Biol. 2015 Aug;65:209-21
pubmed: 26073129
Transl Oncol. 2013 Dec 01;6(6):757-65
pubmed: 24466379