Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study.

Aged Aqueous Humor / metabolism Biomarkers / metabolism Cross-Sectional Studies Female Filtering Surgery / methods Glaucoma / metabolism Humans Intraocular Pressure / physiology Male Metabolomics / methods
Aqueous humor Glaucoma Metabolomics Nuclear magnetic resonance spectroscopy Open-angle glaucoma

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
12 2020
Historique:
received: 24 06 2020
revised: 06 09 2020
accepted: 21 09 2020
pubmed: 5 10 2020
medline: 2 3 2021
entrez: 4 10 2020
Statut: ppublish

Résumé

Glaucoma is still a poorly understood disease with a clear need for new biomarkers to help in diagnosis and potentially offer new therapeutic targets. We aimed to determine if the metabolic profile of aqueous humor (AH) as determined by nuclear magnetic resonance (NMR) spectroscopy allows the distinction between primary open-angle glaucoma patients and control subjects, and to distinguish between high-tension (POAG) and normal-tension glaucoma (NTG). We analysed the AH of patients with POAG, NTG and control subjects (n = 30/group).

Identifiants

DOI: 10.1016/j.exer.2020.108268 PMID: 33011236
pubmed: 33011236
pii: S0014-4835(20)30526-1
doi: 10.1016/j.exer.2020.108268
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108268

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

João Barbosa Breda (J)

Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Cardiovascular R&D Center, Faculty of Medicine of the University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal; Department of Ophthalmology, Centro Hospitalar e Universitário São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal. Electronic address: joao.breda@chsj.min-saude.pt.

Anca Croitor Sava (A)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Molecular Small Animal Imaging Center (MoSAIC), KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Uwe Himmelreich (U)

Biomedical MRI Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Molecular Small Animal Imaging Center (MoSAIC), KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Alix Somers (A)

Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Christophe Matthys (C)

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism, and Aging, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Clinical Nutrition, Department of Endocrinology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Amândio Rocha Sousa (A)

Cardiovascular R&D Center, Faculty of Medicine of the University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal; Department of Ophthalmology, Centro Hospitalar e Universitário São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Evelien Vandewalle (E)

Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Ingeborg Stalmans (I)

Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Humeur aqueuse › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie ophtalmologique › Chirurgie filtrante › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Pression intraoculaire › Metabolomic profiling of aqueous humor from...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Metabolomic profiling of aqueous humor from...