Quantitative analysis of inner retinal structural and microvascular alterations in intermediate age-related macular degeneration: A swept-source OCT angiography study.
Age-related macular degeneration
Ganglion cell complex
Vessel density, OCT
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
22
08
2020
revised:
20
09
2020
accepted:
25
09
2020
pubmed:
5
10
2020
medline:
11
5
2021
entrez:
4
10
2020
Statut:
ppublish
Résumé
To investigate the structural and microvascular alterations of the inner retinal layers in patients with intermediate age-related macular degeneration (iAMD), and determine an association between structural and microvascular parameters. In this prospective study, 58 eyes of iAMD patients and 64 age and sex-matched control eyes were enrolled. Participants underwent spectral-domain optical coherence tomography (OCT) and swept-source OCT angiography (OCTA) imaging. Retinal layer segmentation was performed automatically using the built-in software of the OCT device. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) thicknesses were analyzed in the central and parafoveal region. Foveal avascular zone (FAZ) area and vessel density of the superficial and deep capillary plexuses (SCP and DCP) in the fovea and parafoveal region were obtained. In iAMD eyes, the RNFL, GCL, and IPL were significantly thinner compared to control eyes in the parafovea (p < 0.05 all). The overall parafoveal SCP vessel density significantly decreased in iAMD eyes compared to the controls (p = 0.022). There was also a non-significant reduction in DCP vessel density measurements in iAMD eyes compared to controls (p > 0.05 all). The ganglion cell complex was significantly correlated with SCP vessel density measurements in iAMD eyes (r = 0.224, p = 0.043). This study demonstrates that the inner retina is effected in iAMD in terms of structural and microvascular components. Inner retinal thinning is significantly correlated with vessel density reduction, suggesting a cause and effect relationship between these parameters. Further longitudinal studies may aid in characterizing these alterations to better understand AMD pathogenesis.
Identifiants
pubmed: 33011396
pii: S1572-1000(20)30384-7
doi: 10.1016/j.pdpdt.2020.102030
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102030Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.