TAM and TIM receptors mRNA expression in Zika virus infected placentas.
Case-Control Studies
Female
Hepatitis A Virus Cellular Receptor 1
/ metabolism
Host-Pathogen Interactions
Humans
Interferon Type I
/ metabolism
Interferons
/ metabolism
Placenta
/ enzymology
Pregnancy
Pregnancy Complications, Infectious
/ immunology
Proto-Oncogene Proteins
/ metabolism
Receptor Protein-Tyrosine Kinases
/ metabolism
Zika Virus
/ physiology
Zika Virus Infection
/ immunology
Interferon Lambda
Axl Receptor Tyrosine Kinase
Interferons
Placenta
TAM receptors
TIM receptors
Zika virus.
mRNA expression
Journal
Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
20
07
2020
revised:
20
09
2020
accepted:
21
09
2020
pubmed:
5
10
2020
medline:
21
10
2021
entrez:
4
10
2020
Statut:
ppublish
Résumé
To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.
Identifiants
pubmed: 33011564
pii: S0143-4004(20)30362-3
doi: 10.1016/j.placenta.2020.09.062
pii:
doi:
Substances chimiques
HAVCR1 protein, human
0
Hepatitis A Virus Cellular Receptor 1
0
Interferon Type I
0
Proto-Oncogene Proteins
0
Interferons
9008-11-1
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
TYRO3 protein, human
EC 2.7.10.1
Interferon Lambda
0
Axl Receptor Tyrosine Kinase
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
204-207Investigateurs
Eliana Amaral
(E)
Helaine Maria Besteti Pires Mayer-Milanez
(HM)
Carolina C Ribeiro-do-Valle
(CC)
Roseli Calil
(R)
João Renato Bennini Junior
(JR)
Giuliane Jesus Lajos
(GJ)
Albina Altemani
(A)
Maria Luiza Moretti
(ML)
Mariangela Ribeiro Resende
(MR)
Márcia Teixeira Garcia
(MT)
Rodrigo Nogueira Angerami
(RN)
Marcos Tadeu Nolasco da Silva
(MT)
Ana Carolina Coan
(AC)
Maria Francisca Colella-Santos
(MF)
Andrea Paula Bruno von Zuben
(AP)
André Ricardo Ribas Freitas
(AR)
Marco Aurélio Ramirez Vinolo
(MA)
Rodrigo Ramos Catharino
(RR)
Fábio Trindade Maranhão Costa
(FT)
Clarice Weis Arns
(CW)
Aline Vieira
(A)
Gabriela Fabiano de Souza
(G)
Karina Bispo Dos Santos
(K)
Mariene Ribeiro Amorim
(MR)
Matheus Cavalheiro Martini
(MC)
Stéfanie Primon Muraro
(SP)
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.