Traumatic brain injury-induced cerebral microbleeds in the elderly.
Ageing
Brain trauma
Cerebral microhaemorrhage
Microbleed
Mild traumatic brain injury
Vascular changes
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
16
06
2020
accepted:
23
09
2020
pubmed:
5
10
2020
medline:
1
6
2021
entrez:
4
10
2020
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function.
Identifiants
pubmed: 33011936
doi: 10.1007/s11357-020-00280-3
pii: 10.1007/s11357-020-00280-3
pmc: PMC8050119
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-136Subventions
Organisme : National Institute of Health
ID : R01-NS100782
Organisme : National Institute of Health
ID : R01-AT006526
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
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