Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP):: A Randomized Double-Blind Placebo-Controlled Feasibility Trial.
Adult
Angiotensin-Converting Enzyme Inhibitors
/ adverse effects
Blood Pressure
/ drug effects
Cardiovascular Physiological Phenomena
/ drug effects
Cough
/ chemically induced
Double-Blind Method
Echocardiography
Enalapril
/ adverse effects
Exanthema
/ chemically induced
Feasibility Studies
Female
Hemodynamics
/ drug effects
Humans
Infant, Newborn
Pre-Eclampsia
/ physiopathology
Pregnancy
Treatment Outcome
Ventricular Function, Left
/ drug effects
angiotensin-converting enzyme
cardiovascular disease
echocardiography
enalapril
left ventricular remodeling
postpartum
pregnancy
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
6
10
2020
medline:
4
5
2021
entrez:
5
10
2020
Statut:
ppublish
Résumé
Hypertensive disease in pregnancy is associated with future cardiovascular disease and, therefore, provides an opportunity to identify women who could benefit from targeted interventions aimed at reducing cardiovascular morbidity. This study focused on the highest-risk group, women with preterm preeclampsia, who have an 8-fold risk of death from future cardiovascular disease. We performed a single-center feasibility randomized controlled trial of 6 months' treatment with enalapril to improve postnatal cardiovascular function. Echocardiography and hemodynamic measurements were performed at baseline (<3 days), 6 weeks, and 6 months postdelivery on 60 women. At randomization, 88% of women had diastolic dysfunction, and 68% had concentric remodeling/hypertrophy. No difference was seen in total vascular resistance (
Identifiants
pubmed: 33012200
doi: 10.1161/HYPERTENSIONAHA.120.15875
pmc: PMC7610547
mid: EMS119244
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Enalapril
69PN84IO1A
Banques de données
ClinicalTrials.gov
['NCT03466333']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1828-1837Subventions
Organisme : British Heart Foundation
ID : FS/12/57/29717
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R001693/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Références
Nitric Oxide. 2018 Nov 1;80:37-44
pubmed: 30099096
Circulation. 2019 Sep 24;140(13):1050-1060
pubmed: 31545680
PLoS One. 2015 Apr 08;10(4):e0122336
pubmed: 25853818
Placenta. 2009 Jun;30(6):473-82
pubmed: 19375795
Cardiovasc Ultrasound. 2015 Apr 15;13:19
pubmed: 25880324
J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):402-9
pubmed: 18077832
Eur J Clin Pharmacol. 1990;38(1):99
pubmed: 2158450
Paediatr Perinat Epidemiol. 2010 Jul 1;24(4):323-30
pubmed: 20618721
Eur J Echocardiogr. 2010 Jan;11(1):51-6
pubmed: 19910319
Arch Intern Med. 2011 Jun 27;171(12):1082-7
pubmed: 21709107
N Engl J Med. 2000 Jan 20;342(3):145-53
pubmed: 10639539
Hypertension. 2011 Jul;58(1):57-62
pubmed: 21606389
Placenta. 2002 May;23(5):359-72
pubmed: 12061851
Circulation. 2019 Feb 19;139(8):1069-1079
pubmed: 30779636
Pregnancy Hypertens. 2014 Apr;4(2):97-104
pubmed: 26104417
Pediatr Pathol Mol Med. 2002 May-Jun;21(3):279-90
pubmed: 12056503
Hypertension. 2012 Aug;60(2):444-50
pubmed: 22753220
Hypertension. 2009 Jun;53(6):944-51
pubmed: 19433776
BMJ. 2001 Nov 24;323(7323):1213-7
pubmed: 11719411
BJOG. 2005 Nov;112(11):1486-91
pubmed: 16225567
BMJ. 2009 Jun 18;338:b2255
pubmed: 19541696
N Engl J Med. 1990 May 31;322(22):1561-6
pubmed: 2139921
Hypertension. 2016 Nov;68(5):1153-1159
pubmed: 27620393
Echo Res Pract. 2020 Feb 24;7(1):G1-G18
pubmed: 32105051
JACC Cardiovasc Imaging. 2018 Aug;11(8):1196-1201
pubmed: 30092974
Circulation. 1992 Aug;86(2):431-8
pubmed: 1638712
Hypertension. 2016 Apr;67(4):748-53
pubmed: 26902488
Acta Obstet Gynecol Scand. 1998 Sep;77(8):808-13
pubmed: 9776593
Circ Cardiovasc Imaging. 2010 Sep;3(5):614-22
pubmed: 20581050
Eur Heart J. 1998 Mar;19(3):481-9
pubmed: 9568453
Am Heart J. 2008 Nov;156(5):918-30
pubmed: 19061708
J Pregnancy. 2019 Mar 03;2019:9795765
pubmed: 30941219
Ultrasound Obstet Gynecol. 2017 Dec;50(6):683-696
pubmed: 28078751
Hypertension. 2020 Jun;75(6):1334-1357
pubmed: 32370572
Hypertension. 2018 Apr;71(4):742-751
pubmed: 29483222
Lancet. 2001 Jun 23;357(9273):2002-6
pubmed: 11438131
Hypertension. 2011 Oct;58(4):709-15
pubmed: 21844489
BMJ. 2013 Feb 25;346:f894
pubmed: 23440270
J Hypertens. 2011 Apr;29(4):769-76
pubmed: 21330936
Cochrane Database Syst Rev. 2007 Apr 18;(2):CD006490
pubmed: 17443623
Circulation. 2001 Feb 13;103(6):799-805
pubmed: 11171786
Herz. 2003 Dec;28(8):744-53
pubmed: 14689110
Hypertension. 2008 Apr;51(4):1020-6
pubmed: 18259001
J Am Coll Cardiol. 1995 Mar 15;25(4):879-84
pubmed: 7884091
Lancet. 2000 Jan 22;355(9200):253-9
pubmed: 10675071
J Am Coll Cardiol. 1999 Nov 1;34(5):1625-32
pubmed: 10551715
J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14
pubmed: 25559473
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S9.e1, S9-11
pubmed: 26428507
J Am Heart Assoc. 2018 Sep 18;7(18):e009259
pubmed: 30371205
Circ Cardiovasc Imaging. 2018 Nov;11(11):e008031
pubmed: 30571317
Heart. 2020 Dec;106(24):1927-1933
pubmed: 32404402
Circulation. 2019 Apr 2;139(14):1698-1709
pubmed: 30760000
BMJ. 2007 Nov 10;335(7627):974
pubmed: 17975258
Curr Hypertens Rep. 2016 Dec;18(12):89
pubmed: 27889904