Targeting Mast Cells with Biologics.

Allergens / administration & dosage Animals Biological Products / pharmacology Cell Proliferation / drug effects Clinical Trials as Topic Cytokines / metabolism Desensitization, Immunologic / methods Disease Models, Animal Humans Hypersensitivity / immunology Mast Cells / drug effects Mastocytosis / immunology Signal Transduction / drug effects Treatment Outcome
Hereditary alpha tryptasemia Immunotherapy Mast cell activation Mastocytosis Monoclonal

Journal

Immunology and allergy clinics of North America
ISSN: 1557-8607
Titre abrégé: Immunol Allergy Clin North Am
Pays: United States
ID NLM: 8805635

Informations de publication

Date de publication:
11 2020
Historique:
entrez: 5 10 2020
pubmed: 6 10 2020
medline: 5 10 2021
Statut: ppublish

Résumé

Mast cells are tissue-resident allergic effector cells that cause many symptoms associated with IgE-mediated immediate hypersensitivity reactions. Beginning with allergen-specific therapy over a century ago, biologics have been used to target mast cells in patients in order to reduce allergic symptoms and reactions. This review discusses the history and current outlook of the use of biologics in mast cell-associated diseases and reactions.

Identifiants

DOI: 10.1016/j.iac.2020.06.007 PMID: 33012327
pubmed: 33012327
pii: S0889-8561(20)30042-4
doi: 10.1016/j.iac.2020.06.007
pii:
doi:

Substances chimiques

Allergens 0
Biological Products 0
Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

667-685

Informations de copyright

Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Disclosure The authors declare no competing or conflicting interests.

Auteurs

Jonathan J Lyons (JJ)

Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institutes of Health, 9000 Rockville Pike, Building 29B, Room 5NN18, MSC 1889, Bethesda, MD 20892, USA. Electronic address: jonathan.lyons@nih.gov.

Dean D Metcalfe (DD)

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, BG 10 RM 11N244B, 10 Center Drive, Bethesda, MD 20814, USA.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Eucaryotes › Animaux › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Désensibilisation immunologique › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mastocytes › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Maladies du système immunitaire › Troubles de l'activation mastocytaire › Mastocytose › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Targeting Mast Cells with Biologics.
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Targeting Mast Cells with Biologics.