The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain.
cannabinoids
formalin test
persistent pain
rats
sex differences
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
04
2020
accepted:
21
07
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to treat pain, is a sesquiterpene found in large amounts in the essential oils of various spice and food plants such as oregano, cinnamon, and black pepper. It binds to the CB2 receptor, acting as a full agonist. Sex differences in the BCP-induced analgesic effect were studied by exposing male and female rats to a persistent/repeated painful stimulation. To simulate treatment of a repeated inflammatory condition, after the first formalin injection (FT1; 50 μl, 2.5%), rats received BCP
Identifiants
pubmed: 33013287
doi: 10.3389/fnins.2020.00850
pmc: PMC7461959
doi:
Types de publication
Journal Article
Langues
eng
Pagination
850Informations de copyright
Copyright © 2020 Ceccarelli, Fiorenzani, Pessina, Pinassi, Aglianò, Miragliotta and Aloisi.
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