miRNA Alterations Elicit Pathways Involved in Memory Decline and Synaptic Function in the Hippocampus of Aged Tg4-42 Mice.
Alzheimer
NGS
Tg4-42
miRNA transcriptome
miRNA-Seq
transgenic mouse model
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
07
2020
accepted:
18
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
The transcriptome of non-coding RNA (ncRNA) species is increasingly focused in Alzheimer's disease (AD) research. NcRNAs comprise, among others, transfer RNAs, long non-coding RNAs and microRNAs (miRs), each with their own specific biological function. We used smallRNASeq to assess miR expression in the hippocampus of young (3 month old) and aged (8 month old) Tg4-42 mice, a model system for sporadic AD, as well as age-matched wildtype controls. Tg4-42 mice express N-truncated Aβ
Identifiants
pubmed: 33013313
doi: 10.3389/fnins.2020.580524
pmc: PMC7511553
doi:
Types de publication
Journal Article
Langues
eng
Pagination
580524Informations de copyright
Copyright © 2020 Bouter, Kacprowski, Rößler, Jensen, Kuss and Bayer.
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