Functions of p38 MAP Kinases in the Central Nervous System.
astrocyte
central nervous system
microglia
mitogen activated protein (MAP) kinase p38
neuron
oligodendrocyte
signal transduction
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
06
2020
accepted:
18
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system. Unique and specific functions of the four mammalian p38 kinases are found in all major cell types in the brain. Mechanisms of p38 activation and downstream phosphorylation substrates in these different contexts are outlined and how they contribute to functions of p38 in physiological and under disease conditions. Results in different model organisms demonstrated that p38 kinases are involved in cognitive functions, including functions related to anxiety, addiction behavior, neurotoxicity, neurodegeneration, and decision making. Finally, the role of p38 kinases in psychiatric and neurological conditions and the current progress on therapeutic inhibitors targeting p38 kinases are covered and implicate p38 kinases in a multitude of CNS-related physiological and disease states.
Identifiants
pubmed: 33013322
doi: 10.3389/fnmol.2020.570586
pmc: PMC7509416
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
570586Informations de copyright
Copyright © 2020 Asih, Prikas, Stefanoska, Tan, Ahel and Ittner.
Références
J Neuroinflammation. 2019 May 10;16(1):98
pubmed: 31077217
J Biol Chem. 1995 Mar 31;270(13):7420-6
pubmed: 7535770
Cell Death Dis. 2018 May 22;9(6):596
pubmed: 29789529
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Neuron. 2002 Sep 26;36(1):57-68
pubmed: 12367506
Mol Cell Biol. 2011 Jan;31(2):256-66
pubmed: 21078877
Neuron. 2008 Mar 13;57(5):746-59
pubmed: 18341994
J Neurosci. 2020 May 6;40(19):3741-3750
pubmed: 32321746
Nat Biotechnol. 2005 Mar;23(3):329-36
pubmed: 15711537
Neuron. 2007 Jun 7;54(5):771-85
pubmed: 17553425
Biochem J. 2009 Mar 15;418(3):475-89
pubmed: 19228121
J Cereb Blood Flow Metab. 2008 Oct;28(10):1686-96
pubmed: 18545259
Neuropharmacology. 2010 Mar;58(3):561-8
pubmed: 19951717
J Neurosci. 2015 Sep 2;35(35):12303-8
pubmed: 26338340
J Neurosci. 2012 Sep 5;32(36):12325-36
pubmed: 22956823
Cell. 2009 Sep 4;138(5):1005-18
pubmed: 19737525
Nature. 1994 Jun 9;369(6480):488-91
pubmed: 8202139
Neuron. 2007 Nov 8;56(3):456-71
pubmed: 17988630
Atherosclerosis. 2015 Jun;240(2):490-6
pubmed: 25913664
Cold Spring Harb Perspect Biol. 2015 Jul 01;7(7):a021758
pubmed: 26134321
Dev Dyn. 2007 Dec;236(12):3383-92
pubmed: 17994546
J Biol Chem. 2007 Sep 14;282(37):27020-9
pubmed: 17631503
Neurochem Int. 2007 Dec;51(8):459-66
pubmed: 17583386
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
J Biol Chem. 2015 Apr 24;290(17):10814-27
pubmed: 25724654
J Biol Chem. 1998 Oct 30;273(44):28766-72
pubmed: 9786874
J Neurosci. 2014 Apr 9;34(15):5322-34
pubmed: 24719110
Mol Neurobiol. 2018 Oct;55(10):8084-8102
pubmed: 29508281
Nat Immunol. 2008 Sep;9(9):1019-27
pubmed: 18677317
Neuroscience. 2018 Aug 21;386:175-181
pubmed: 29966722
J Biol Chem. 1999 Aug 13;274(33):23570-6
pubmed: 10438538
Brain Behav Immun. 2017 May;62:64-77
pubmed: 28189715
J Biol Chem. 2008 Jan 25;283(4):1778-85
pubmed: 18042545
J Mol Neurosci. 2015 Feb;55(2):509-18
pubmed: 25012593
J Neurosci. 2010 Oct 13;30(41):13750-9
pubmed: 20943915
Pain. 2004 Jul;110(1-2):281-9
pubmed: 15275778
Neurochem Res. 2007 Feb;32(2):293-302
pubmed: 17235686
Mol Cell Neurosci. 2006 Feb;31(2):218-31
pubmed: 16219474
Science. 1994 Aug 5;265(5173):808-11
pubmed: 7914033
J Biol Chem. 2015 Apr 24;290(17):10791-803
pubmed: 25752609
Life Sci. 2006 Oct 12;79(20):1895-905
pubmed: 16978658
J Biol Chem. 2004 Mar 26;279(13):12286-92
pubmed: 14709549
J Biol Chem. 1996 Nov 1;271(44):27205-8
pubmed: 8910287
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51
pubmed: 16537406
Science. 2009 Feb 27;323(5918):1208-1211
pubmed: 19251628
Nature. 1996 Jan 4;379(6560):78-81
pubmed: 8538745
Neuroscience. 1999;93(1):57-69
pubmed: 10430470
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10245-E10254
pubmed: 30297392
Cell Death Differ. 2016 Mar;23(3):542-52
pubmed: 26517532
J Neuroinflammation. 2016 Feb 02;13:27
pubmed: 26838598
J Pharmacol Exp Ther. 1998 Feb;284(2):687-92
pubmed: 9454815
EMBO Rep. 2008 Oct;9(10):1048-54
pubmed: 18704119
Stem Cells Dev. 2010 Nov;19(11):1723-34
pubmed: 20412016
J Neurochem. 2010 Dec;115(6):1350-62
pubmed: 21029094
J Neurosci. 2011 May 4;31(18):6627-38
pubmed: 21543591
J Immunol. 1988 May 15;140(10):3640-5
pubmed: 2452194
J Neurosci. 2008 Mar 19;28(12):3190-201
pubmed: 18354022
J Neurosci Res. 2000 Jun 1;60(5):623-31
pubmed: 10820433
J Cell Biol. 2018 Jan 2;217(1):315-328
pubmed: 29196462
Nat Rev Mol Cell Biol. 2013 Jun;14(6):393-8
pubmed: 23636498
J Neurosci. 2013 Feb 6;33(6):2313-25
pubmed: 23392662
FEBS J. 2013 Jan;280(2):489-504
pubmed: 22812510
J Biol Chem. 2004 Nov 5;279(45):47040-9
pubmed: 15284239
Neurology. 2007 Dec 11;69(24):2236-42
pubmed: 18071143
FEBS Lett. 1997 Jun 2;409(1):57-62
pubmed: 9199504
Hum Mol Genet. 2007 Jul 1;16(13):1604-18
pubmed: 17504823
Mol Endocrinol. 2004 Jul;18(7):1697-707
pubmed: 15184525
J Cell Biol. 2000 Jun 12;149(6):1207-14
pubmed: 10851018
J Neurosci. 2013 May 8;33(19):8185-201
pubmed: 23658158
Trends Pharmacol Sci. 2003 Oct;24(10):535-41
pubmed: 14559406
Biochem J. 2003 May 15;372(Pt 1):193-201
pubmed: 12583813
PLoS Biol. 2014 Aug 05;12(8):e1001923
pubmed: 25093460
Biochem J. 2004 Apr 1;379(Pt 1):133-9
pubmed: 14680475
J Biol Chem. 1998 Jun 26;273(26):16415-20
pubmed: 9632706
J Neuroinflammation. 2011 Jul 06;8:79
pubmed: 21733175
Eur J Neurosci. 2004 Jan;19(2):273-9
pubmed: 14725621
Brain Res. 2011 Mar 25;1382:109-17
pubmed: 21276773
Neuroscience. 2009 Sep 29;163(1):490-9
pubmed: 19345722
Genes Dev. 2003 Aug 15;17(16):1969-78
pubmed: 12893778
Nat Genet. 2007 Jun;39(6):741-9
pubmed: 17468757
J Mol Cell Cardiol. 2005 Apr;38(4):617-23
pubmed: 15808838
Neurochem Res. 2007 Dec;32(12):2160-6
pubmed: 17594516
Mol Cell Neurosci. 2004 Jun;26(2):354-64
pubmed: 15207859
Lancet Neurol. 2019 Aug;18(8):748-759
pubmed: 31229470
PLoS One. 2013 Jun 12;8(6):e65235
pubmed: 23776455
J Biol Chem. 2016 Jan 29;291(5):2067-79
pubmed: 26663083
Physiol Rev. 2001 Apr;81(2):807-69
pubmed: 11274345
PLoS One. 2015 Dec 29;10(12):e0145843
pubmed: 26714323
Science. 2002 Feb 15;295(5558):1291-4
pubmed: 11847341
Oncogene. 2004 Apr 12;23(16):2838-49
pubmed: 15077147
J Cereb Blood Flow Metab. 2002 Apr;22(4):444-52
pubmed: 11919515
Sci Rep. 2013;3:2089
pubmed: 23807566
Nat Commun. 2018 Mar 9;9(1):1017
pubmed: 29523821
Brain Res. 2014 Mar 10;1551:45-58
pubmed: 24440774
J Neurosci. 2012 Dec 5;32(49):17582-96
pubmed: 23223282
Brain Res. 2001 Feb 16;892(1):70-7
pubmed: 11172750
Sci Rep. 2015 Aug 21;5:13416
pubmed: 26293199
Psychopharmacology (Berl). 2005 Nov;183(1):118-26
pubmed: 16184376
Mol Cell Neurosci. 2003 Jun;23(2):180-92
pubmed: 12812752
Neurosci Lett. 2011 Sep 1;501(3):132-7
pubmed: 21777656
J Biol Chem. 1997 Nov 7;272(45):28373-80
pubmed: 9353295
PLoS One. 2015 Oct 09;10(10):e0139914
pubmed: 26452228
J Neurochem. 2012 Sep;122(5):911-22
pubmed: 22708976
Neuron. 2018 Jul 11;99(1):13-27
pubmed: 30001506
Free Radic Biol Med. 2015 Oct;87:312-25
pubmed: 26164633
EMBO J. 2005 Mar 23;24(6):1134-45
pubmed: 15729360
Sci Rep. 2014 Dec 12;4:7405
pubmed: 25502009
Oncogene. 2002 Apr 4;21(15):2387-97
pubmed: 11948422
Front Immunol. 2017 Oct 09;8:1259
pubmed: 29062315
J Biol Chem. 2013 Aug 9;288(32):23331-47
pubmed: 23798682
J Neurosci. 2015 Sep 16;35(37):12917-31
pubmed: 26377476
J Neurosci Res. 2003 Dec 15;74(6):884-90
pubmed: 14648593
J Neurosci. 2003 Aug 13;23(19):7317-25
pubmed: 12917365
Front Cell Neurosci. 2014 Oct 14;8:319
pubmed: 25352781
Cell Death Dis. 2018 Jun 13;9(6):700
pubmed: 29899409
PLoS Genet. 2015 Dec 11;11(12):e1005733
pubmed: 26657059
Exp Neurol. 2008 Oct;213(2):257-67
pubmed: 18590729
J Neural Transm (Vienna). 2001;108(12):1383-96
pubmed: 11810403
Acta Neuropathol. 2020 Sep;140(3):279-294
pubmed: 32725265
Brain Res. 2014 Dec 17;1593:1-8
pubmed: 25451097
Behav Brain Res. 2015 Jan 15;277:136-45
pubmed: 25086269
J Neurosci. 2009 Jul 8;29(27):8858-70
pubmed: 19587293
Ann N Y Acad Sci. 2002 May;962:332-46
pubmed: 12076985
J Neurochem. 2003 Sep;86(6):1534-44
pubmed: 12950462
Stem Cell Reports. 2019 Jun 11;12(6):1313-1328
pubmed: 31080114
Mol Cell Biol. 2013 Jan;33(1):127-35
pubmed: 23109423
J Neurosci. 2013 Apr 3;33(14):6143-53
pubmed: 23554495
Neurosci Lett. 2012 Dec 7;531(2):125-30
pubmed: 23123784
Brain Res Mol Brain Res. 2002 Nov 15;107(2):137-44
pubmed: 12425942
Nat Neurosci. 2007 Apr;10(4):436-43
pubmed: 17369826
J Neurochem. 2015 Aug;134(4):629-41
pubmed: 25951993
J Neurosci. 2007 Oct 24;27(43):11614-23
pubmed: 17959804
Sci Rep. 2017 Dec;7(1):115
pubmed: 28273913
J Neurochem. 2017 Apr;141(1):37-47
pubmed: 27973735
Nat Rev Drug Discov. 2007 May;6(5):391-403
pubmed: 17473844
J Neurosci. 2014 Apr 9;34(15):5285-90
pubmed: 24719106
PLoS One. 2013;8(2):e56852
pubmed: 23457629
Mol Cell Biol. 2005 Jun;25(12):4853-62
pubmed: 15923604
J Neurosci. 2009 Jul 22;29(29):9330-43
pubmed: 19625523
Elife. 2016 Jan 05;5:
pubmed: 26731517
J Neurosci Res. 2003 Aug 15;73(4):537-44
pubmed: 12898538
J Neurosci. 2010 Jan 13;30(2):573-82
pubmed: 20071520
Protein Sci. 2020 May;29(5):1196-1210
pubmed: 32189389
J Pharmacol Exp Ther. 2001 Feb;296(2):312-21
pubmed: 11160612
Neuron. 2004 Aug 19;43(4):563-74
pubmed: 15312654
Glia. 2010 Aug 15;58(11):1384-93
pubmed: 20607863
Neurosci Lett. 2015 Sep 14;604:69-74
pubmed: 26240995
Science. 2002 Oct 25;298(5594):846-50
pubmed: 12399596
J Neurosci. 2009 Sep 23;29(38):11982-92
pubmed: 19776284
Nat Commun. 2019 Sep 11;10(1):4125
pubmed: 31511515
Hum Mol Genet. 2009 Nov 1;18(21):4035-45
pubmed: 19648294
Handb Exp Pharmacol. 2006;(175):197-214
pubmed: 16722237
J Neurosci. 2002 Jul 15;22(14):6121-8
pubmed: 12122073
Cell Death Dis. 2015 May 07;6:e1748
pubmed: 25950478
Endocrinology. 2005 Sep;146(9):3773-81
pubmed: 15947002
Sci Rep. 2017 Mar 31;7:45306
pubmed: 28361984
J Neurosci. 2012 Dec 5;32(49):17714-24
pubmed: 23223292
J Neurosci. 2013 Jul 31;33(31):12764-78
pubmed: 23904612
Aging Dis. 2019 Dec 1;10(6):1302-1310
pubmed: 31788341
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11200-5
pubmed: 22733747
J Recept Signal Transduct Res. 2007;27(2-3):99-111
pubmed: 17613723
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
Cell Res. 2005 Jan;15(1):11-8
pubmed: 15686620
Mol Cell. 2000 Jul;6(1):109-16
pubmed: 10949032
Brain Res. 2004 Nov 19;1027(1-2):73-86
pubmed: 15494159
PLoS One. 2015 Oct 30;10(10):e0141968
pubmed: 26517365
FEBS Lett. 1995 May 8;364(2):229-33
pubmed: 7750577
Neuron. 2013 Mar 6;77(5):942-54
pubmed: 23473323
FEBS J. 2015 May;282(10):1841-57
pubmed: 25728574
J Neurosci. 2008 Oct 15;28(42):10696-710
pubmed: 18923045
J Biol Rhythms. 2014 Dec;29(6):411-26
pubmed: 25403440
PLoS One. 2013 Jun 26;8(6):e66226
pubmed: 23840427
J Biol Chem. 2000 Dec 22;275(51):40641-8
pubmed: 11010976
Molecules. 2017 Aug 02;22(8):
pubmed: 28767069
Brain Res. 2005 May 31;1045(1-2):185-98
pubmed: 15910777
EMBO J. 2016 Mar 1;35(5):536-52
pubmed: 26843485
Cytokine. 2000 Jul;12(7):874-80
pubmed: 10880231
Neurobiol Dis. 2013 Nov;59:26-37
pubmed: 23859799
PLoS Biol. 2016 Apr 12;14(4):e1002440
pubmed: 27070899
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4027-32
pubmed: 23431133
Sci Rep. 2017 Sep 22;7(1):12178
pubmed: 28939911
Neuron. 2013 Oct 30;80(3):704-17
pubmed: 24183021
Eur J Neurosci. 2011 Oct;34(7):1093-101
pubmed: 21939459
J Neurosci. 2008 Nov 19;28(47):12500-9
pubmed: 19020042
Hum Mol Genet. 2006 Jan 15;15(2):273-85
pubmed: 16330479
Stroke. 2010 Dec;41(12):2744-9
pubmed: 20966416
J Neurosci. 2013 Nov 6;33(45):17814-26
pubmed: 24198371
Nat Rev Neurosci. 2016 Jun;17(6):337-50
pubmed: 27080385
Clin Gastroenterol Hepatol. 2006 Mar;4(3):325-34
pubmed: 16527696
J Biol Chem. 2006 Aug 18;281(33):23658-67
pubmed: 16774924
Biochem J. 2010 Aug 1;429(3):403-17
pubmed: 20626350
Neuron. 2011 Aug 11;71(3):498-511
pubmed: 21835346
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12066-71
pubmed: 23818595
Autophagy. 2016 Dec;12(12):2516-2520
pubmed: 27715387
J Immunol. 2005 Aug 15;175(4):2237-43
pubmed: 16081791
J Neurosci. 2002 May 1;22(9):3445-53
pubmed: 11978821
Mol Cell Biol. 1999 Jan;19(1):21-30
pubmed: 9858528
Cell Death Differ. 2008 Sep;15(9):1450-9
pubmed: 18437159
Acta Pharmacol Sin. 2005 Aug;26(8):934-42
pubmed: 16038625
Aging (Albany NY). 2010 Sep;2(9):597-611
pubmed: 20844314
Neuroscience. 2016 Apr 5;319:155-67
pubmed: 26827945
EMBO J. 2007 Feb 7;26(3):635-46
pubmed: 17255949
Mol Cell Biol. 2010 May;30(9):2206-19
pubmed: 20194617
Neurobiol Dis. 2004 Oct;17(1):77-88
pubmed: 15350968
J Biol Chem. 2003 Jul 4;278(27):25166-71
pubmed: 12719413
Front Pharmacol. 2017 Feb 17;8:72
pubmed: 28261102
Cell. 2005 Feb 11;120(3):407-20
pubmed: 15707898
Neurosci Lett. 2000 Dec 22;296(2-3):101-4
pubmed: 11108991
Neurobiol Dis. 2007 May;26(2):332-41
pubmed: 17346981
Mol Cell Biol. 2005 Dec;25(23):10454-64
pubmed: 16287858
EMBO J. 2009 Apr 22;28(8):1043-54
pubmed: 19300439
Alzheimers Res Ther. 2016 Dec 15;8(1):54
pubmed: 27974048
Nat Commun. 2014 Aug 19;5:4701
pubmed: 25134715
Neuropharmacology. 2003 Mar;44(3):374-80
pubmed: 12604095
PLoS One. 2008 May 07;3(5):e2130
pubmed: 18461158
Ann N Y Acad Sci. 1999 Apr 30;868:38-50
pubmed: 10414280
J Neurosci. 2011 Aug 24;31(34):12059-67
pubmed: 21865449
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7561-6
pubmed: 10852968
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5819-24
pubmed: 21421841
J Biol Chem. 1997 Jul 25;272(30):18518-21
pubmed: 9228012
Int J Mol Sci. 2018 Mar 15;19(3):
pubmed: 29543752
Lancet Neurol. 2016 Jul;15(8):869-881
pubmed: 27180033
Trends Mol Med. 2007 Feb;13(2):54-63
pubmed: 17207662
Cold Spring Harb Perspect Biol. 2012 Nov 01;4(11):
pubmed: 23125017
Sci Rep. 2017 Mar 03;7:43153
pubmed: 28256519
Neuropharmacology. 2011 Sep;61(3):421-32
pubmed: 21466815
Mol Cell Biol. 2002 Jul;22(13):4827-35
pubmed: 12052889
J Prev Alzheimers Dis. 2017;4(4):273-278
pubmed: 29181493
J Alzheimers Dis. 2012;32(3):587-97
pubmed: 22886009
Cell. 1991 May 17;65(4):663-75
pubmed: 2032290
Arthritis Rheum. 2009 May;60(5):1232-41
pubmed: 19404957
PLoS Genet. 2014 Aug 21;10(8):e1004565
pubmed: 25144774
J Neurosci Res. 2010 Jul;88(9):1970-84
pubmed: 20143421
J Neurosci. 2006 Nov 15;26(46):11992-2002
pubmed: 17108173
Biochim Biophys Acta. 2007 Aug;1773(8):1358-75
pubmed: 17481747
J Biol Chem. 2005 Nov 11;280(45):37599-609
pubmed: 16157584
Acta Neuropathol Commun. 2014 Oct 21;2:149
pubmed: 25331068
Neuroreport. 2010 Mar 10;21(4):313-7
pubmed: 20134354
Exp Neurol. 2003 Oct;183(2):394-405
pubmed: 14552880
Cell. 1997 Aug 8;90(3):549-58
pubmed: 9267034
Curr Med Chem. 2011;18(10):1526-39
pubmed: 21428890
FEBS Lett. 2004 Sep 24;575(1-3):136-40
pubmed: 15388348
Nat Genet. 2007 Jun;39(6):750-8
pubmed: 17468755
FEBS J. 2007 Feb;274(4):963-75
pubmed: 17241234
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5428-33
pubmed: 23509252
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9
pubmed: 21768366
PLoS One. 2011;6(10):e26999
pubmed: 22046431
Neuroscience. 2013 Dec 3;253:435-43
pubmed: 24012839
Science. 2007 May 4;316(5825):750-4
pubmed: 17478722
Science. 2015 Feb 20;347(6224):878-82
pubmed: 25700520
Trends Neurosci. 2003 Feb;26(2):81-9
pubmed: 12536131
Lancet Neurol. 2018 Jul;17(7):629-640
pubmed: 29914708
J Neurochem. 2007 Aug;102(3):977-90
pubmed: 17442041
Behav Brain Res. 2017 Mar 30;322(Pt B):212-222
pubmed: 27765672
Nature. 1994 Dec 22-29;372(6508):739-46
pubmed: 7997261
FEBS J. 2013 Dec;280(23):5981-93
pubmed: 23663200
PLoS One. 2009 Nov 20;4(11):e7934
pubmed: 19936205
J Neurosci. 2006 Feb 8;26(6):1721-9
pubmed: 16467520
Cell Cycle. 2005 Sep;4(9):1189-92
pubmed: 16103752
Sci Rep. 2016 Jun 10;6:27600
pubmed: 27283322
J Cell Physiol. 2006 Feb;206(2):363-70
pubmed: 16110469
Sci Rep. 2017 Feb 13;7:42370
pubmed: 28205565
Cell. 2010 Aug 6;142(3):387-97
pubmed: 20655099
J Biol Chem. 2004 Oct 29;279(44):45308-11
pubmed: 15375157
PLoS Pathog. 2018 Sep 20;14(9):e1007283
pubmed: 30235355
Sci Rep. 2018 May 30;8(1):8392
pubmed: 29849065
Front Aging Neurosci. 2017 Sep 29;9:317
pubmed: 29033828
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130145
pubmed: 24298147
J Neurosci. 2008 Mar 26;28(13):3521-30
pubmed: 18367618
PLoS One. 2013 Dec 23;8(12):e83049
pubmed: 24376630
Stroke. 2004 Feb;35(2):520-6
pubmed: 14726553
Nat Immunol. 2005 Apr;6(4):390-5
pubmed: 15735648
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:11-20
pubmed: 30853341
J Med Chem. 2019 Dec 12;62(23):10757-10782
pubmed: 31702918
Science. 2016 Nov 18;354(6314):904-908
pubmed: 27856911
J Pharmacol Exp Ther. 2000 Apr;293(1):281-8
pubmed: 10734180
Sci Rep. 2017 Jan 20;7:40865
pubmed: 28106089
Cell. 1994 Sep 23;78(6):1027-37
pubmed: 7923353
J Neurosci. 2010 Feb 3;30(5):1637-47
pubmed: 20130174
Mol Cell Biol. 2002 Jan;22(2):599-613
pubmed: 11756555
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
J Cell Sci. 2005 Jan 15;118(Pt 2):397-408
pubmed: 15632108
Stem Cells. 2006 May;24(5):1399-406
pubmed: 16424397
Mol Med Today. 1999 Oct;5(10):439-47
pubmed: 10498912
Neuropsychopharmacology. 2018 Jun;43(7):1492-1497
pubmed: 29472645
J Biol Chem. 1998 Jan 16;273(3):1741-8
pubmed: 9430721
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006338
pubmed: 22762015
J Neurosci. 2015 May 27;35(21):8258-71
pubmed: 26019340
Acta Neuropathol. 2012 Apr;123(4):573-86
pubmed: 22302101
J Biol Chem. 2006 Feb 24;281(8):4771-8
pubmed: 16361255
EMBO J. 1998 Dec 15;17(24):7337-50
pubmed: 9857190
Immunol Res. 2000;21(2-3):233-7
pubmed: 10852122
Glia. 2012 Jul;60(7):1130-44
pubmed: 22511272
Nat Rev Neurosci. 2011 Feb;12(2):65-72
pubmed: 21193853
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10738-43
pubmed: 21670305
Neuron. 2005 Jan 6;45(1):81-94
pubmed: 15629704
J Neurochem. 2005 Mar;92(6):1508-20
pubmed: 15748168
J Cell Biochem. 2010 Aug 15;110(6):1420-9
pubmed: 20506250
Autophagy. 2015;11(8):1425-7
pubmed: 26061537
Brain. 2016 Sep;139(Pt 9):2486-502
pubmed: 27538418
J Med Chem. 2003 Oct 23;46(22):4676-86
pubmed: 14561087
J Exp Med. 2012 Nov 19;209(12):2229-46
pubmed: 23129748
Physiol Rev. 1999 Jan;79(1):143-80
pubmed: 9922370
J Biol Chem. 1997 Nov 28;272(48):30122-8
pubmed: 9374491
J Neurosci. 2005 Jul 13;25(28):6621-30
pubmed: 16014723
Biologics. 2008 Sep;2(3):419-31
pubmed: 19707373
J Neurosci Res. 2001 Sep 1;65(5):425-31
pubmed: 11536326
Genes Brain Behav. 2012 Jul;11(5):586-600
pubmed: 22405502
Transl Psychiatry. 2015 Nov 03;5:e671
pubmed: 26529424
Mol Pharmacol. 2007 Dec;72(6):1476-83
pubmed: 17848599
J Mol Neurosci. 2015 Oct;57(2):185-96
pubmed: 26067431
Glia. 2007 Nov 15;55(15):1531-41
pubmed: 17729284
FEBS Open Bio. 2015 May 08;5:437-44
pubmed: 26101740
J Exp Med. 2013 Nov 18;210(12):2553-67
pubmed: 24166713
J Neurol Sci. 2001 Oct 15;191(1-2):35-41
pubmed: 11676990
Cell Signal. 2004 Oct;16(10):1113-21
pubmed: 15240006
Mol Cell Biol. 2005 Apr;25(7):2733-43
pubmed: 15767678
Cell. 2009 Jan 23;136(2):235-48
pubmed: 19135240
Sci Rep. 2018 Sep 24;8(1):14296
pubmed: 30250211
Biochim Biophys Acta. 2007 Aug;1773(8):1150-60
pubmed: 17229475
J Biol Chem. 2004 Aug 20;279(34):35903-13
pubmed: 15192112
Neuron. 2006 Dec 7;52(5):831-43
pubmed: 17145504
Cell. 1994 Sep 23;78(6):1039-49
pubmed: 7923354
Biochem Biophys Res Commun. 1998 Aug 28;249(3):791-6
pubmed: 9731215
Oncogene. 2004 Nov 18;23(54):8766-76
pubmed: 15480425
J Cell Biol. 2005 Jan 3;168(1):117-26
pubmed: 15631993
Brain Res Mol Brain Res. 2001 Oct 19;94(1-2):157-65
pubmed: 11597776
Adv Exp Med Biol. 2012;970:307-31
pubmed: 22351062
Neuropsychopharmacology. 2018 Jan;43(2):362-372
pubmed: 28649993
BMB Rep. 2009 Mar 31;42(3):142-7
pubmed: 19336000
J Physiol. 2008 May 15;586(10):2499-510
pubmed: 18356198
J Neurosci. 1998 Sep 1;18(17):6892-904
pubmed: 9712659