Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons.
afferent tracing
breathing
modified rabies
neural circuit
preBötzinger Complex
respiration
retrograde tracing
Journal
Frontiers in neuroanatomy
ISSN: 1662-5129
Titre abrégé: Front Neuroanat
Pays: Switzerland
ID NLM: 101477943
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
02
2020
accepted:
04
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
The key driver of breathing rhythm is the preBötzinger Complex (preBötC) whose activity is modulated by various functional inputs, e.g., volitional, physiological, and emotional. While the preBötC is highly interconnected with other regions of the breathing central pattern generator (bCPG) in the brainstem, there is no data about the direct projections to either excitatory and inhibitory preBötC subpopulations from other elements of the bCPG or from suprapontine regions. Using modified rabies tracing, we identified neurons throughout the brain that send monosynaptic projections to identified excitatory and inhibitory preBötC neurons in mice. Within the brainstem, neurons from sites in the bCPG, including the contralateral preBötC, Bötzinger Complex, the nucleus of the solitary tract (NTS), parafacial region (pF
Identifiants
pubmed: 33013329
doi: 10.3389/fnana.2020.00058
pmc: PMC7507425
doi:
Types de publication
Journal Article
Langues
eng
Pagination
58Subventions
Organisme : NEI NIH HHS
ID : R01 EY022577
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH063912
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS072211
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135779
Pays : United States
Informations de copyright
Copyright © 2020 Yang, Kim, Callaway and Feldman.
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