NK and T Cell Differentiation at the Maternal-Fetal Interface in Sows During Late Gestation.
Animals
Cell Differentiation
/ immunology
Cells, Cultured
Female
Immunologic Memory
/ immunology
Killer Cells, Natural
/ immunology
Leukocytes, Mononuclear
Lymphocyte Activation
/ immunology
Maternal-Fetal Relations
/ physiology
Perforin
/ immunology
Placenta
/ immunology
Pregnancy
Receptors, Antigen, T-Cell, gamma-delta
/ immunology
Swine
T-Lymphocytes
/ immunology
CD4 T cells
CD8 T cells
flow cytometry
late gestation
natural killer cells
porcine placenta
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
07
2020
accepted:
21
08
2020
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
23
6
2021
Statut:
epublish
Résumé
The phenotype and function of immune cells that reside at the maternal-fetal interface in humans and mice have been, and still are, extensively studied with the aim to fully comprehend the complex immunology of pregnancy. In pigs, information regarding immune cell phenotypes is limited and mainly focused on early gestation whereas late gestation has not yet been investigated. We designed a unique methodology tailored to the porcine epitheliochorial placenta, which allowed us to address immune phenotypes separately in the maternal endometrium (ME) and fetal placenta (FP) by flow cytometry. In-depth phenotyping of NK cells, non-conventional and conventional T cells within maternal blood (mBld), ME, FP, and fetal spleen (fSpln) revealed major differences between these anatomic sites. In both maternal compartments, all NK cells were perforin
Identifiants
pubmed: 33013937
doi: 10.3389/fimmu.2020.582065
pmc: PMC7516083
doi:
Substances chimiques
Receptors, Antigen, T-Cell, gamma-delta
0
Perforin
126465-35-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
582065Informations de copyright
Copyright © 2020 Stas, Koch, Stadler, Sawyer, Sassu, Mair, Saalmüller, Gerner and Ladinig.
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