The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid

Aged Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Female Gray Matter / metabolism Humans Male Middle Aged Retina / metabolism Synapses / metabolism Visual Cortex / metabolism

Journal

Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417

Informations de publication

Date de publication:
2020
Historique:
received: 24 04 2020
revised: 19 08 2020
accepted: 24 08 2020
entrez: 5 10 2020
pubmed: 6 10 2020
medline: 14 9 2021
Statut: epublish

Résumé

The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer's disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we examined the associations between retinal changes and molecular and structural markers of cortical damage. We recruited 20 AD patients and 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), and positron emission tomography (PET) imaging, we measured retinal and primary visual cortex (V1) thicknesses, along with V1 amyloid

Identifiants

DOI: 10.1155/2020/8826087 PMID: 33014034 PMC: PMC7525303
pubmed: 33014034
doi: 10.1155/2020/8826087
pmc: PMC7525303
doi:

Substances chimiques

Amyloid beta-Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8826087

Informations de copyright

Copyright © 2020 Lília Jorge et al.

Déclaration de conflit d'intérêts

The authors have no conflict of interest to report.

Références

J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Front Psychol. 2014 Feb 07;5:74
pubmed: 24570669
Neurology. 1995 Jan;45(1):68-74
pubmed: 7824139
J Psychiatr Res. 1982-1983;17(1):37-49
pubmed: 7183759
Annu Rev Cell Dev Biol. 2001;17:255-96
pubmed: 11687490
Alzheimer Dis Assoc Disord. 2013 Jan-Mar;27(1):37-43
pubmed: 22193353
Neurobiol Aging. 2013 Jul;34(7):1799-806
pubmed: 23465714
J Neuroophthalmol. 2006 Mar;26(1):18-24
pubmed: 16518161
ISRN Neurol. 2013 Sep 25;2013:989583
pubmed: 24187629
Invest Ophthalmol Vis Sci. 2007 May;48(5):2285-9
pubmed: 17460292
Micron. 2012 Jul;43(7):759-81
pubmed: 22445096
J Alzheimers Dis. 2016 Sep 6;54(2):585-95
pubmed: 27567815
Int Ophthalmol. 2014 Dec;34(6):1203-11
pubmed: 25284015
Semin Ophthalmol. 2003 Jun;18(2):50-7
pubmed: 14566623
J Nucl Med. 2009 Mar;50(3):348-55
pubmed: 19223409
Neurochem Res. 2011 Jan;36(1):163-9
pubmed: 20936504
Lancet. 2003 Apr 12;361(9365):1258-65
pubmed: 12699953
Optom Vis Sci. 1996 Nov;73(11):677-82
pubmed: 8950748
Neurology. 1996 Jan;46(1):121-5
pubmed: 8559359
Science. 2002 Oct 25;298(5594):789-91
pubmed: 12399581
Exp Aging Res. 2005 Jan-Mar;31(1):15-33
pubmed: 15842071
Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):390-402
pubmed: 31468182
Doc Ophthalmol. 2010 Oct;121(2):111-21
pubmed: 20549299
Nat Rev Neurol. 2013 Jan;9(1):44-53
pubmed: 23165340
J Gerontol. 1994 Mar;49(2):P52-7
pubmed: 8126359
Gerontologist. 1969 Autumn;9(3):179-86
pubmed: 5349366
Neurobiol Aging. 2013 Apr;34(4):1133-44
pubmed: 23084085
Ophthalmology. 1990 Jan;97(1):9-17
pubmed: 2314849
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Ann Neurol. 2016 Jan;79(1):90-109
pubmed: 26505992
Acta Ophthalmol. 2015 Jun;93(4):e241-7
pubmed: 25482990
Neurobiol Aging. 1994 Jan-Feb;15(1):29-43
pubmed: 8159261
IEEE Rev Biomed Eng. 2010;3:169-208
pubmed: 22275207
Dement Geriatr Cogn Disord. 2009;27(6):501-7
pubmed: 19451717
IEEE Trans Pattern Anal Mach Intell. 2006 Jan;28(1):119-34
pubmed: 16402624
Prog Retin Eye Res. 2014 Sep;42:44-84
pubmed: 24984227
Neurology. 1999 Jan 1;52(1):71-7
pubmed: 9921851
Brain. 2010 Jun;133(Pt 6):1575-7
pubmed: 20511281
Trans R Soc Trop Med Hyg. 2009 Jul;103(7):661-4
pubmed: 19100590
J Cereb Blood Flow Metab. 2003 Sep;23(9):1096-112
pubmed: 12973026
Clin Neurol Neurosurg. 2011 Sep;113(7):523-6
pubmed: 21454010
Neurosci Lett. 2015 Jan 1;584:12-6
pubmed: 25451722
IEEE Trans Med Imaging. 2009 Sep;28(9):1436-47
pubmed: 19278927
J Neurosci. 2011 Jan 26;31(4):1333-40
pubmed: 21273418
J Neurosci. 1987 Jun;7(6):1799-808
pubmed: 2439665
Neurobiol Aging. 1996 May-Jun;17(3):377-84
pubmed: 8725899
Invest Ophthalmol Vis Sci. 2013 Sep 05;54(9):5953-8
pubmed: 23920375
J Alzheimers Dis. 2019;70(3):723-732
pubmed: 31282416
Cereb Cortex. 2013 Oct;23(10):2489-99
pubmed: 22879351
Neurosci Lett. 2010 Aug 9;480(1):69-72
pubmed: 20609426
Arch Gerontol Geriatr. 2015 Jan-Feb;60(1):162-7
pubmed: 25459918
Acta Ophthalmol Scand. 2001 Apr;79(2):187-91
pubmed: 11284761
Nat Rev Neurosci. 2001 Aug;2(8):595-8
pubmed: 11484003
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
Curr Neurol Neurosci Rep. 2015 Apr;15(4):17
pubmed: 25716012
Neurobiol Aging. 1993 Sep-Oct;14(5):471-7
pubmed: 8247229
Alzheimers Dement (Amst). 2017 Nov 06;10:49-55
pubmed: 29201990
Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):871-80
pubmed: 23364356
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):793-800
pubmed: 18791173
Exp Eye Res. 2011 Apr;92(4):244-50
pubmed: 21310146
Front Cell Neurosci. 2016 Feb 04;10:20
pubmed: 26869887
Clin Neurophysiol. 2001 Oct;112(10):1860-7
pubmed: 11595144
Brain. 2009 May;132(Pt 5):1128-45
pubmed: 19336464
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Alzheimers Dement. 2014 Mar;10(2):251-61
pubmed: 24011928
Expert Opin Ther Targets. 2016 Jun;20(6):653-61
pubmed: 26652296
J Alzheimers Dis. 2015;45(1):45-56
pubmed: 25428254
Vision Res. 2011 Feb 9;51(3):386-95
pubmed: 21156185
PLoS One. 2015 Aug 07;10(8):e0134750
pubmed: 26252902
Neurol Clin. 2003 Aug;21(3):709-28
pubmed: 13677819
Nat Cell Biol. 2004 Nov;6(11):1054-61
pubmed: 15516999
Wiley Interdiscip Rev Syst Biol Med. 2009 Nov-Dec;1(3):380-389
pubmed: 20836003
Front Aging Neurosci. 2020 Jan 08;11:360
pubmed: 31998115
Neurosci Lett. 2007 Jun 13;420(2):97-9
pubmed: 17543991
Front Neurol. 2016 Apr 19;7:55
pubmed: 27148157
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
J Alzheimers Dis. 2012;28(4):885-96
pubmed: 22112549
PLoS One. 2012;7(12):e53547
pubmed: 23300938
Am J Ophthalmol. 1985 Jul 15;100(1):68-72
pubmed: 3893141
Rev Esp Med Nucl Imagen Mol. 2013 Sep-Oct;32(5):301-9
pubmed: 23933381
Surv Ophthalmol. 1989 Jul-Aug;34(1):31-43
pubmed: 2678551
Invest Ophthalmol Vis Sci. 1995 Jan;36(1):24-31
pubmed: 7822152
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
J Neurol. 2014 Aug;261(8):1522-30
pubmed: 24846203
Neuroimage. 2013 Jan 15;65:336-48
pubmed: 23041529
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Appl Neuropsychol Adult. 2015;22(4):311-9
pubmed: 25531579
Ann N Y Acad Sci. 1991;640:36-43
pubmed: 1776757
Neuroimage. 2011 Jan;54 Suppl 1:S204-17
pubmed: 20550967
J Alzheimers Dis. 2013;34(3):659-64
pubmed: 23271313
J Cereb Blood Flow Metab. 2012 Aug;32(8):1600-8
pubmed: 22588187
Neuroimage Clin. 2018 Aug 19;20:603-610
pubmed: 30186764

Auteurs

Lília Jorge (L)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
ORCID: 0000-0001-7683-2987

Nádia Canário (N)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.

Ricardo Martins (R)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
ORCID: 0000-0001-7184-185X

Beatriz Santiago (B)

Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal.
Department of Neurology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

Isabel Santana (I)

Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal.
Department of Neurology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

Hugo Quental (H)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal.

Francisco Ambrósio (F)

Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal.
Department of Neurology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.
Coimbra Institute for Clinical and Biomedical Research (iCBR), Retinal Dysfunction & Neuroinflammation Lab, Coimbra, Portugal.

Rui Bernardes (R)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
ORCID: 0000-0002-6677-2754

Miguel Castelo-Branco (M)

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
ORCID: 0000-0003-4364-6373

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › The Retinal Inner Plexiform Synaptic Layer...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex visuel › The Retinal Inner Plexiform Synaptic Layer...