New Aspects of the Epigenetics of Pancreatic Carcinogenesis.
Journal
Epigenomes
ISSN: 2075-4655
Titre abrégé: Epigenomes
Pays: Switzerland
ID NLM: 101736595
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
ppublish
Résumé
Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribute to disease progression, neither genetic nor environmental factors completely explain susceptibility or pathogenesis. Defining the links between genetic and environmental events represents an opportunity to understand the pathogenesis of pancreatic cancer. Epigenetics, the study of mitotically heritable changes in genome function without a change in nucleotide sequence, is an emerging field of research in pancreatic cancer. The main epigenetic mechanisms include DNA methylation, histone modifications and RNA interference, all of which are altered by changes to the environment. Epigenetic mechanisms are being investigated to clarify the underlying pathogenesis of pancreatic cancer including an increasing number of studies examining the role as possible diagnostic and prognostic biomarkers. These mechanisms also provide targets for promising new therapeutic approaches for this devastating malignancy.
Identifiants
pubmed: 33014438
doi: 10.3390/epigenomes4030018
pmc: PMC7528595
mid: NIHMS1630427
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA136526
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors declare no conflict of interest.
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