Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage.
aging
apoptosis
cartilage
chaperones
endoplasmic reticulum stress
osteoarthritis
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
10
06
2019
accepted:
30
11
2019
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Aging is a major risk factor for the development of osteoarthritis (OA). One hallmark of aging is loss of proteostasis resulting in increased cellular stress and cell death. However, its effect on the development of OA is not clear. Here, using knee articular cartilage tissue from young and old cynomolgus monkeys (
Identifiants
pubmed: 33014525
doi: 10.14336/AD.2019.1130
pii: ad-11-5-1091
pmc: PMC7505268
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1091-1102Subventions
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR066105
Pays : United States
Informations de copyright
copyright: © 2020 Tan et al.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflict of interests.
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