Pyroptosis Plays a Role in Osteoarthritis.
caspase
inflammation
osteoarthritis
pyroptosis
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
19
08
2019
accepted:
27
11
2019
entrez:
5
10
2020
pubmed:
6
10
2020
medline:
6
10
2020
Statut:
epublish
Résumé
Recent studies have revealed novel forms of cell death beyond the canonical types of cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme microenvironmental factors. Pyroptosis, a type of regulated cell death, occurs when pattern recognition receptors (PRRs) induce the activation of cysteine-aspartic protease 1 (caspase-1) or caspase-11, which can trigger the release of the pyrogenic cytokines interleukin-1β (IL-1β) and IL-18. Osteoarthritis (OA), the most common joint disease worldwide, is characterized by low-grade inflammation and increased levels of cytokines, including IL-1β and IL-18. Additionally, some damaged chondrocytes associated with OA exhibit morphological changes consistent with pyroptosis, suggesting that this form of regulated cell death may contribute significantly to the pathology of OA. This review summarizes the molecular mechanisms of pyroptosis and shows the critical role of NLRP3 (NLR family, pyrin domain containing 3; NLR refers to "nucleotide-binding domain, leucine-rich repeat") inflammasomes. We also provide evidence describing potential role of pyroptosis in OA, including the relationship with OA risk factors and the contribution to cartilage degradation, synovitis and OA pain.
Identifiants
pubmed: 33014529
doi: 10.14336/AD.2019.1127
pii: ad-11-5-1146
pmc: PMC7505276
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1146-1157Informations de copyright
copyright: © 2020 An et al.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare that they have no conflicts of interest pertaining to this study.
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